PMID: 12788474Jun 6, 2003Paper

Enhancing effect of melatonin on chemiluminescence accompanying decomposition of hydrogen peroxide in the presence of copper

Free Radical Biology & Medicine
Aleksandra KładnaIrena Kruk

Abstract

The oxidation of melatonin (MEL) using the Cu(II) + H(2)O(2) + HO(-) (the Fenton-like reaction) system was investigated by chemiluminescence (CL), fluorescence, spectrophotometric, and EPR spin trapping techniques. The reaction exhibits CL in the 400-730 nm region. The light emission from the Fenton-like reaction was greatly enhanced in the presence of MEL and was strongly dependent on its concentration. The spectrum measured with cut-off filters revealed maxima at around 460, 500, 580-590, 640-650, and 690-700 nm. The band at 460 nm may be due to the excited cleavage product, N(1)-acetyl-N(2)-formyl-5-methoxykynuramine, whereas the bands at 500, 580-590, 640-650, and 700 nm were similar to those observed for singlet molecular oxygen ((1)O(2)). The effect of reactive oxygen species (ROS) scavengers on the light emission was studied. The CL was strongly inhibited by the (1)O(2) scavengers in a dose-dependent manner; at concentration 1 mM the potency of (1)O(2) scavenging was 5,5-dimethylcyclohexandione-1,3 > methionine > histidine > hydroquinone. The potency of HO(*) scavenging by thiourea, tryptophan, cysteine at concentration 5 mM was 79-94%, by 1 mM glutathione and trolox 75 and 94%, respectively, and by 10 mM cimetidine 18%....Continue Reading

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