PMID: 8961160Nov 1, 1996Paper

Enhancing effects of unsaturated fatty acids with various structures on the permeation of indomethacin through rat skin

The Journal of Pharmacy and Pharmacology
K MorimotoM Kakemi

Abstract

Effects of straight-chain, cis-type, unsaturated fatty acids with various structures (alkyl chain lengths, numbers of double bonds, position of double bonds, and cis- and trans-positional isomers) on the skin permeation of indomethacin were examined by using rat skins in-vitro. Furthermore, the disordering degrees of the intercellular lipid domain in the stratum corneum, which were treated with preparations of unsaturated fatty acids, were measured by the Fourier transform infrared (FT-IR) method using excised rabbit ear skins. Unsaturated fatty acids enhanced the permeation of indomethacin through rat skins. These permeation-enhancing effects by unsaturated fatty acids were affected by changes of their alkyl chain length from C14 to C22. The lag-times on the permeation of indomethacin were shortened by unsaturated fatty acids in the following order: C20 = C18 = C22 < C16 < C14. These fluxes were increased by unsaturated fatty acids in the following order: C20 > C22 = C18 = C16 > C14. Therefore, gondoic acid (cis-11-eicosenoic acid; C20H38O2) mostly enhanced the skin permeation of indomethacin. However, the enhancing effects of unsaturated fatty acids (C18 chain) were not affected by their differences of position and numbers of...Continue Reading

References

Mar 1, 1991·Pharmaceutical Research·B OngpipattanakulM L Francoeur
Jan 1, 1987·Journal of Pharmaceutical Sciences·G M GoldenR O Potts
Nov 1, 1981·Journal of Pharmacobio-dynamics·K YamaokaT Uno

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Citations

Feb 13, 2001·International Journal of Pharmaceutics·H J OhC K Kim
Sep 2, 2004·Biological & Pharmaceutical Bulletin·Aiping WangKazuhiro Morimoto
Feb 1, 2014·Archives of Dermatological Research·Umesh K Patil, Richa Saraogi
Aug 8, 2008·Drug Delivery·Min-Jung KimHan-Gon Choi
Aug 14, 2012·Medicinal Research Reviews·Josef Jampilek, Katerina Brychtova
Jun 16, 2016·Physical Chemistry Chemical Physics : PCCP·Anna AkinshinaMassimo G Noro
Jan 8, 2020·Expert Opinion on Drug Delivery·Andrej KováčikKateřina Vávrová
Oct 12, 2019·Scientific Reports·Monika KopečnáKateřina Vávrová
Jun 18, 2020·Frontiers in Pharmacology·Erin M MooreSlavko Komarnytsky
Jan 8, 2021·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Yuki UminoMitsuhiro Denda

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