Enhancing glioblastoma treatment using cisplatin-gold-nanoparticle conjugates and targeted delivery with magnetic resonance-guided focused ultrasound

Nanomedicine : Nanotechnology, Biology, and Medicine
Daniel ColucciaJames T Rutka

Abstract

Glioblastoma (GBM) is the most common and aggressive primary brain tumor resulting in high rates of morbidity and mortality. A strategy to increase the efficacy of available drugs and enhance the delivery of chemotherapeutics through the blood brain barrier (BBB) is desperately needed. We investigated the potential of Cisplatin conjugated gold nanoparticle (GNP-UP-Cis) in combination with MR-guided Focused Ultrasound (MRgFUS) to intensify GBM treatment. Viability assays demonstrated that GNP-UP-Cis greatly inhibits the growth of GBM cells compared to free cisplatin and shows marked synergy with radiation therapy. Additionally, increased DNA damage through γH2AX phosphorylation was observed in GNP-UP-Cis treated cells, along with enhanced platinum concentrations. In vivo, GNP-UP-Cis greatly reduced the growth of GBM tumors and MRgFUS led to increased BBB permeability and GNP-drug delivery in brain tissue. Our studies suggest that GNP-Cis conjugates and MRgFUS can be used to focally enhance the delivery of targeted chemotherapeutics to brain tumors.

Citations

Aug 14, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Steven ZanganehMorteza Mahmoudi
Sep 7, 2019·Nanotechnology·Kai WuJian-Ping Wang
Jan 23, 2020·Cancers·Edouard Alphandéry
Feb 19, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Biagio De AngelisLuciano De Sio
Jan 28, 2020·Journal of Chemotherapy·Vahid RezaeiFarzaneh Khademi
Sep 30, 2018·Journal of Molecular Neuroscience : MN·Liang YangZongmao Zhao
Oct 23, 2019·Pharmaceutics·Okhil K Nag, James B Delehanty
May 23, 2020·Bioengineering & Translational Medicine·Kevin LiawRangaramanujam M Kannan
Jan 20, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Dimitrios Giakoumettis, Spyros Sgouros
Dec 10, 2020·Heliyon·Viviane de Cassia Jesus da SilvaStephen Fernandes Rodrigues
Dec 22, 2020·International Journal of Radiation Oncology, Biology, Physics·Hong-Jian WeiCheng-Chia Wu
Oct 28, 2020·Nature Reviews. Neurology·Ying MengNir Lipsman
Dec 3, 2020·International Journal of Molecular Sciences·Joanna DepciuchMagdalena Parlinska-Wojtan
Nov 15, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Joji IshidaJames Rutka
Nov 17, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Phoebe McCrorieRuman Rahman
Jun 11, 2021·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Tao TangTaolei Sun
May 22, 2020·ACS Medicinal Chemistry Letters·Alessio MolinariMaurizio Botta
Aug 19, 2021·Neuromolecular Medicine·Muna Aryal, Tyrone Porter
Sep 4, 2021·Beilstein Journal of Nanotechnology·Sepand Tehrani FatehAmin Shiralizadeh Dezfuli
Nov 28, 2021·Pharmaceutics·Rory WhelanAndrew J S Knox
Jan 7, 2022·Biomaterials Science·Ruiqi LiJinghua Ren
Jan 19, 2022·Journal of Internal Medicine·Sneha RathiWilliam F Elmquist

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