Enhancing immunity prevents virus-induced T-cell-mediated immunopathology in B cell-deficient mice

European Journal of Immunology
Tobias Straub, H Pircher

Abstract

Hyper-activated or deviated immune responses can result in immunopathological diseases. Paradoxically, immunodeficiency represents a frequent cause of such immune-mediated pathologies. Immunopathological manifestations are commonly treated by immunosuppression, but in situations in which immunodeficiency is the basis of disease development, enhancing immunity may represent an alternative treatment option. Here, we tested this counterintuitive concept in a preclinical model using infection of mice with lymphocytic choriomeningitis virus (LCMV). Firstly, we demonstrate that infection of B-cell-deficient (B-/- ) but not of wild-type (WT) mice with the LCMV strain Docile induced a rapid and fatal CD8+ T-cell-mediated immunopathological disease. Similar to WT mice, LCMV-infected B-/- mice generated a potent, functional LCMV-specific CD8+ T-cell response but exhibited prolonged viral antigen presentation and increased vascular leakage in liver and lungs. Secondly, we were able to prevent this virus-induced immunopathology in B-/- mice by active or passive T-cell immunizations or by treatment with LCMV-specific virus neutralizing or non-neutralizing monoclonal antibodies (mAb). Thus, boosting antiviral immunity did not aggravate immun...Continue Reading

References

May 1, 1996·The Journal of Experimental Medicine·M S Asano, R Ahmed
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martijn A NolteReina E Mebius
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer LoutenChristine A Biron
Apr 10, 2009·PLoS Biology·Andreas BergthalerDaniel D Pinschewer
Dec 12, 2012·The Journal of Experimental Medicine·Helge FrebelAnnette Oxenius
Jun 12, 2013·European Journal of Immunology·Kirsten Richter, Annette Oxenius
Jun 12, 2013·European Journal of Immunology·Tobias StraubHanspeter Pircher
Jun 4, 2014·Proceedings of the National Academy of Sciences of the United States of America·Roberto BaccalaMichael B A Oldstone
Oct 21, 2015·Current Opinion in Allergy and Clinical Immunology·Annick A J M van de Ven, Klaus Warnatz
Nov 21, 2015·PLoS Pathogens·Rami SommersteinDaniel D Pinschewer
Oct 13, 2017·European Journal of Immunology·Andrea CossarizzaJakob Zimmermann
Aug 1, 2018·Proceedings of the National Academy of Sciences of the United States of America·Michael B A OldstoneBrian M Sullivan

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BETA
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FlowJo
GraphPad InStat
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