Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping

Human Molecular Genetics
S SawcerJ L Haines

Abstract

To explore the potential value of recently developed high-density linkage mapping methods in the analysis of complex disease we have regenotyped five nuclear families first studied in the 1996 UK multiple sclerosis linkage genome screen, using Applied Biosystems high-density microsatellite linkage mapping set, the Illumina BeadArray linkage mapping panel (version 3) and the Affymetrix GeneChip Human Mapping 10K array. We found that genotyping success, information extraction and genotyping accuracy were improved with all systems. These improvements were particularly marked with the SNP-based methods (Illumina and Affymetrix), with little difference between these. The extent of additional information extracted is considerable, indicating that reanalysis of existing multiplex families using these newer systems would substantially increase power.

Citations

Mar 18, 2006·Current Diabetes Reports·Craig L Hanis, D Hallman
Mar 22, 2006·Oncogene·L J EngleJ E Landers
Aug 14, 2008·Nucleic Acids Research·Nigel M WilliamsMichael C O'Donovan
Jun 16, 2005·Current Opinion in Rheumatology·Stuart H Ralston
Feb 3, 2006·BMC Genetics·Douglas F Levinson, Peter Holmans
Oct 19, 2006·PLoS Genetics·Michael F SeldinPeter K Gregersen
Aug 5, 2005·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Diane Hu-LinceDietrich A Stephan
Feb 26, 2010·Annals of Indian Academy of Neurology·Stephen Sawcer
May 21, 2008·Brain : a Journal of Neurology·Stephen Sawcer
Aug 9, 2011·Annual Review of Pharmacology and Toxicology·Ann K Daly
Aug 26, 2014·Journal of Endocrinological Investigation·N Alonso, S H Ralston
Apr 19, 2005·Expert Review of Molecular Diagnostics·David W Craig, Dietrich A Stephan
Mar 4, 2006·Expert Review of Molecular Diagnostics·Jiannis Ragoussis, Gareth Elvidge
Apr 1, 2007·Expert Opinion on Drug Discovery·Allen D Roses
Feb 10, 2007·Rheumatic Diseases Clinics of North America·Omar M E Albagha, Stuart H Ralston
Mar 26, 2005·Immunological Reviews·David A HaflerClare Baecher-Allan
Dec 13, 2006·Biometrics·Valentina Moskvina, Karl Michael Schmidt
Jun 7, 2005·Chemico-biological Interactions·Martyn T SmithNathaniel Rothman
Apr 28, 2006·American Journal of Human Genetics·Joel GelernterHenry R Kranzler
Dec 29, 2005·American Journal of Human Genetics·Tadao ArinamiUNKNOWN Japanese Schizophrenia Sib-Pair Linkage Group
Dec 8, 2006·Osteoarthritis and Cartilage·Stuart H Ralston
Aug 5, 2005·American Journal of Human Genetics·Stephen SawcerUNKNOWN International Multiple Sclerosis Genetics Consortium
Aug 16, 2006·American Journal of Human Genetics·E M GillandersJ E Bailey-Wilson
Mar 2, 2005·Nature Reviews. Genetics·Abdallah S Daar, Peter A Singer
Jan 5, 2005·Nature Reviews. Immunology·David A Hafler, Philip L De Jager
Feb 18, 2005·Nature Reviews. Genetics·Joel N Hirschhorn, Mark J Daly
May 14, 2005·Current Opinion in Neurology·Saleh M Ibrahim, Ralf Gold
Dec 21, 2006·Molecular Psychiatry·D Q MaM A Pericak-Vance
Dec 16, 2005·Genetic Epidemiology·Charalampos Papachristou, Shili Lin
May 1, 2010·Endocrine Reviews·Stuart H Ralston, André G Uitterlinden
Apr 29, 2006·Human Molecular Genetics·Christopher S CarlsonDeborah A Nickerson
May 1, 2007·The Proceedings of the Nutrition Society·Stuart H Ralston
Jan 28, 2009·Journal of Biomolecular Screening·Kaja K SelmerThore Egeland
Apr 23, 2008·Current Protocols in Human Genetics·Simon Gregory, John Gilbert
Jan 12, 2010·Current Protocols in Human Genetics·William S Bush, Jonathan Haines
Feb 10, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Carol A MathewsNicholas J Schork
Sep 19, 2006·Genes & Development·Stuart H Ralston, Benoit de Crombrugghe

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