Enhancing Lysosomal Activation Restores Neural Stem Cell Function During Aging

Journal of Experimental Neuroscience
Amanda J Audesse, Ashley E Webb

Abstract

Adult neurogenesis supports cognitive and sensory functions in mammals and is significantly reduced with age. Quiescent neural stem cells are the source of new neurons in the adult brain and emerging evidence suggests that the failure of these cells to activate and re-enter the cell cycle is largely responsible for reduced neurogenesis in old animals. However, the molecular mechanisms supporting quiescence and activation in the adult and aged brain remain undefined. Recent work published by Leeman et al. in Science uncovers a novel role for lysosomes in supporting neural stem cell activation, and reveals that loss of lysosome function during aging contributes to reduced neural stem cell activity. Using a combination of transcriptomics and functional analysis, the authors show that quiescent and activated neural stem cells employ different branches of proteostasis networks, with quiescent stem cells particularly dependent on the lysosome-autophagy system. Excitingly, stimulation of lysosomal activity in the aged quiescent population significantly enhanced their ability to activate and increased the frequency of activated neural stem and progenitor cells within the neural stem cell niche. This work for the first time identifies l...Continue Reading

References

Sep 24, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Emeka EnwereSamuel Weiss
Jun 28, 2005·Current Opinion in Cell Biology·Fulvio Reggiori, Daniel J Klionsky
Nov 10, 2009·Cell Stem Cell·Valérie M RenaultAnne Brunet
Nov 10, 2009·Cell Stem Cell·Ji-hye PaikRonald A DePinho
Mar 29, 2011·Biochimica Et Biophysica Acta·Nissim Hay
Feb 22, 2012·The EMBO Journal·Carmine SettembreAndrea Ballabio
Apr 19, 2012·Cell Cycle·James R ValcourtHilary A Coller
Jun 14, 2012·Science Signaling·Agnes Roczniak-FergusonShawn M Ferguson
Nov 28, 2012·Frontiers in Genetics·Della C David
Feb 8, 2013·Nature·Matthew R WarrEmmanuelle Passegué
Apr 2, 2013·Nature Neuroscience·Chenran WangJun-Lin Guan
Apr 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mickael DecressacAnders Björklund
Jun 12, 2013·Cell·Carlos López-OtínGuido Kroemer
Aug 22, 2013·Stem Cells·Claudio GiachinoVerdon Taylor
Mar 29, 2014·Glia·Vivian Capilla-GonzalezAlfredo Quiñones-Hinojosa
Apr 22, 2014·Stem Cell Reports·Suchitra D GopinathThomas A Rando
Aug 12, 2014·Scientific Reports·Xiaohui LvJianwei Jiao
Apr 7, 2016·Cold Spring Harbor Perspectives in Biology·Daniel A Lim, Arturo Alvarez-Buylla
Mar 11, 2017·Neuron·Fiona M MenziesDavid C Rubinsztein

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.