Enhancing membrane disruption by targeting and multivalent presentation of antimicrobial peptides

Biochimica Et Biophysica Acta
Cristina ChamorroRoland J Pieters

Abstract

In order to enhance the membrane disruption of antimicrobial peptides both targeting and multivalent presentation approaches were explored. The antimicrobial peptides anoplin and temporin L were conjugated via click chemistry to vancomycin and to di- and tetravalent dendrimers. The vancomycin unit led to enhanced membrane disruption of large unilamellar vesicles (LUVs) displaying the vancomycin target lipid II, but only for temporin L and not for anoplin. The multivalent presentation led to enhanced LUV membrane disruption in the case of anoplin but not for temporin L.

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Related Concepts

1,2-dioleoyl-sn-glycerol-3-ethylphosphocholine
Carboxyfluorescein
1,2-dioleoyl-sn-glycero-3-phosphoglycerol, (Z)-isomer
Melanoma-Associated Antigen 2
Anoplin
Mechanobiology
High Pressure Liquid Chromatography Procedure
Tetraiodofluorescein
Lipids
Polypeptides

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