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Enhancing Potency and Selectivity of a DC-SIGN Glycomimetic Ligand by Fragment-Based Design: Structural Basis

Chemistry : a European Journal

Aug 30, 2019

Laura MedveFranck FIESCHI

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Abstract

Chemical modification of pseudo-dimannoside ligands guided by fragment-based design allowed for the exploitation of an ammonium-binding region in the vicinity of the mannose-binding site of DC-SIGN, leading to the synthesis of a glycomimetic antagonist (compound 16) of unprecedented aff...read more

Mentioned in this Paper

Carbohydrates
Ligands
phosphatidylinositol dimannoside
Site
Evaluation
Binding Protein
Antagonists
Crystal Structure
Fragments
Structure
10
1
1
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Enhancing Potency and Selectivity of a DC-SIGN Glycomimetic Ligand by Fragment-Based Design: Structural Basis

Chemistry : a European Journal

Aug 30, 2019

Laura MedveFranck FIESCHI

PMID: 31469191

DOI: 10.1002/chem.201903391

Abstract

Chemical modification of pseudo-dimannoside ligands guided by fragment-based design allowed for the exploitation of an ammonium-binding region in the vicinity of the mannose-binding site of DC-SIGN, leading to the synthesis of a glycomimetic antagonist (compound 16) of unprecedented aff...read more

Mentioned in this Paper

Carbohydrates
Ligands
phosphatidylinositol dimannoside
Site
Evaluation
10
1
1

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