Enhancing Renal Lymphatic Expansion Prevents Hypertension in Mice

Circulation Research
Catalina A Lopez GelstonJoseph M Rutkowski

Abstract

Hypertension is associated with renal infiltration of activated immune cells; however, the role of renal lymphatics and immune cell exfiltration is unknown. We tested the hypotheses that increased renal lymphatic density is associated with 2 different forms of hypertension in mice and that further augmenting renal lymphatic vessel expansion prevents hypertension by reducing renal immune cell accumulation. Mice with salt-sensitive hypertension or nitric oxide synthase inhibition-induced hypertension exhibited significant increases in renal lymphatic vessel density and immune cell infiltration associated with inflammation. Genetic induction of enhanced lymphangiogenesis only in the kidney, however, reduced renal immune cell accumulation and prevented hypertension. These data demonstrate that renal lymphatics play a key role in immune cell trafficking in the kidney and blood pressure regulation in hypertension.

References

Apr 1, 1988·The American Journal of the Medical Sciences·J M SullivanT E Ratts
Jun 16, 2001·Kidney International·B Rodríguez-IturbeR J Johnson
Jun 16, 2001·American Journal of Physiology. Renal Physiology·Y QuirozB Rodríguez-Iturbe
Mar 22, 2002·The New England Journal of Medicine·Richard J JohnsonBernardo Rodriguez-Iturbe
Feb 24, 2004·Journal of the American Society of Nephrology : JASN·Dontscho KerjaschkiIngrid Raab
Apr 5, 2005·Lupus·A C Allison
Aug 22, 2006·Histopathology·Y IshikawaT Ishii
Jan 27, 2007·The American Journal of Pathology·Florian HellerStephan Segerer
Jan 16, 2009·Kidney International·Izumi SakamotoSeiichi Matsuo
Feb 12, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Carmen De MiguelDavid L Mattson
Feb 20, 2010·Clinical and Experimental Nephrology·Bernardo Rodriguez-Iturbe
May 28, 2010·Clinical and Experimental Hypertension : CHE·Alper SonmezMustafa Kutlu
Jan 22, 2011·Clinical and Experimental Pharmacology & Physiology·Bernardo Rodríguez-IturbeRichard J Johnson
May 25, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Harald SeegerStephan Segerer
Oct 6, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yasmir QuirozBernardo Rodríguez-Iturbe
Feb 1, 2013·American Journal of Physiology. Renal Physiology·Martha FrancoBernardo Rodriguez-Iturbe
Dec 18, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Guo-Hong YangYu-Ming Li
Dec 19, 2014·Circulation·Dariush MozaffarianUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jun 28, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Gabriela M LammogliaJoseph M Rutkowski

❮ Previous
Next ❯

Citations

May 26, 2018·British Journal of Pharmacology·Dakshnapriya BalasubbramanianBrett M Mitchell
Nov 1, 2018·Journal of Cellular Physiology·Shadia BeainiNassim Fares
Apr 14, 2019·Journal of Clinical Medicine·Gábor Csányi, Bhupesh Singla
Apr 5, 2019·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Chia-Wen ChangJonathan W Song
Aug 21, 2019·American Journal of Hypertension·Dakshnapriya BalasubbramanianBrett M Mitchell
Jan 28, 2020·American Journal of Physiology. Renal Physiology·Daniel J Fehrenbach, David L Mattson
Jan 9, 2020·Journal of Hypertension·Dakshnapriya BalasubbramanianJoseph M Rutkowski
May 27, 2020·Basic Research in Cardiology·Ilona CuijpersEbba Brakenhielm
Dec 1, 2019·Aging·Gaurav Baranwal, Joseph M Rutkowski
Jun 7, 2019·Circulation Research·Ruth Williams, UNKNOWN Editors
Jul 19, 2019·Journal of Zhejiang University. Science. B·Xinguo Jiang
Feb 7, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Brian W Wong
Apr 17, 2020·Journal of the American Society of Nephrology : JASN·Daniyal J Jafree, David A Long
Sep 16, 2020·Cellular and Molecular Life Sciences : CMLS·Sudarshan BhattacharjeeHong Chen
Oct 22, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Yijiang ZhouXiaosheng Hu
Oct 8, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Suraj KrishnanRajesh Mohandas
Aug 5, 2020·Cardiovascular Research·Bhupesh SinglaGábor Csányi
Jan 21, 2021·Experimental Biology and Medicine·Heidi A Creed, Joseph M Rutkowski
Mar 7, 2021·Antioxidants·Bhupesh SinglaGábor Csányi
Apr 3, 2021·Molecular and Cellular Endocrinology·Elena Cantero-NavarroAlberto Ortiz
May 25, 2021·Current Opinion in Nephrology and Hypertension·Michael D Donnan
Jun 24, 2021·Nature Reviews. Nephrology·Michael D DonnanSusan E Quaggin
Jul 10, 2021·Cellular and Molecular Life Sciences : CMLS·Xin GengR Sathish Srinivasan
Aug 7, 2021·The FEBS Journal·Giacomo Rossitto, Christian Delles
Sep 24, 2021·Journal of the American Society of Nephrology : JASN·Hao LiuDenise K Marciano
Nov 23, 2021·Physiological Reports·Gaurav BaranwalJoseph M Rutkowski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

British Journal of Pharmacology
Dakshnapriya BalasubbramanianBrett M Mitchell
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Yasmir QuirozBernardo Rodríguez-Iturbe
American Journal of Physiology. Renal Physiology
Sterling C KneedlerBrett M Mitchell
© 2022 Meta ULC. All rights reserved