PMID: 20625650Jul 14, 2010Paper

Enhancing T3 and cAMP responsive gene participation in the thermogenic regulation of fuel oxidation pathways

Arquivos brasileiros de endocrinologia e metabologia
Karina Kores DorsaMagnus R Dias da Silva

Abstract

We sought to identify glycolysis, glycogenolysis, lipolysis, Krebs cycle, respiratory chain, and oxidative phosphorylation enzymes simultaneously regulated by T3 and cAMP. We performed in silico analysis of 56 promoters to search for cis-cAMP (CREB) and cis-thyroid (TRE) response elements, considering UCP1, SERCA2 and glyceraldehyde 3-phosphate dehydrogenase as reference. Only regulatory regions with prior in vitro validation were selected. 29/56 enzymes presented potential TREs in their regulatory sequence, and some scored over 0.80 (better predictive value 1): citrate synthase, phosphoglucose isomerase, succinate dehydrogenases A/C, UCP3, UCP2, UCP4, UCP5, phosphoglycerate mutase, glyceraldehyde 3-P dehydrogenase, glucokinase, malate dehydrogenase, acyl-CoA transferase (thiolase), cytochrome a3, and lactate dehydrogenase. Moreover, some enzymes have not yet been described in the literature as genomically regulated by T3. Our results point to other enzymes which may possibly be regulated by T3 and CREB, and speculate their joint roles in contributing to the optimal thermogenic acclimation.

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Citations

Apr 22, 2014·Insect Biochemistry and Molecular Biology·Michele Alves-BezerraJosé R Meyer-Fernandes
Feb 1, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Haofeng JiJerzy W Kupiec-Weglinski
Mar 2, 2016·Molecular Medicine·Evangelina Delgado-GonzálezBrenda Anguiano

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