Enhancing Tabletop X-Ray Phase Contrast Imaging with Nano-Fabrication

Scientific Reports
Houxun MiaoHan Wen

Abstract

X-ray phase-contrast imaging is a promising approach for improving soft-tissue contrast and lowering radiation dose in biomedical applications. While current tabletop imaging systems adapt to common x-ray tubes and large-area detectors by employing absorptive elements such as absorption gratings or monolithic crystals to filter the beam, we developed nanometric phase gratings which enable tabletop x-ray far-field interferometry with only phase-shifting elements, leading to a substantial enhancement in the performance of phase contrast imaging. In a general sense the method transfers the demands on the spatial coherence of the x-ray source and the detector resolution to the feature size of x-ray phase masks. We demonstrate its capabilities in hard x-ray imaging experiments at a fraction of clinical dose levels and present comparisons with the existing Talbot-Lau interferometer and with conventional digital radiography.

References

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Citations

Nov 2, 2016·Journal of Microelectromechanical Systems : a Joint IEEE and ASME Publication on Microstructures, Microactuators, Microsensors, and Microsystems·Houxun MiaoHan Wen
Nov 20, 2016·Optics Express·M MarschnerF Pfeiffer
Jun 25, 2021·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Alessandro Olivo

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Methods Mentioned

BETA
x-ray imaging
electron beam lithography
X-Ray

Software Mentioned

PaxScan

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