Enhancing the Delivery of Chemotherapeutics: Role of Biodegradable Polymeric Nanoparticles

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Jyoti AhlawatMahesh Narayan

Abstract

While pharmaceutical drugs have revolutionized human life, there are several features that limit their full potential. This review draws attention to some of the obstacles currently facing the use of chemotherapeutic drugs including low solubility, poor bioavailability and high drug dose. Overcoming these issues will further enhance the applicability and potential of current drugs. An emerging technology that is geared towards improving overall therapeutic efficiency resides in drug delivery systems including the use of polymeric nanoparticles which have found widespread use in cancer therapeutics. These polymeric nanoparticles can provide targeted drug delivery, increase the circulation time in the body, reduce the therapeutic indices with minimal side-effects, and accumulate in cells without activating the mononuclear phagocyte system (MPS). Given the inroads made in the field of nanodelivery systems for pharmaceutical applications, it is of interest to review and emphasize the importance of Polymeric nanocarrier system for drug delivery in chemotherapy.

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Citations

Apr 14, 2019·Materials·Jyoti AhlawatMahesh Narayan
Oct 6, 2020·Frontiers in Pharmacology·Enrico LattuadaPatrizia Filetici
Nov 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roxana RacoviceanuCodruţa Şoica
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Nishant S KulkarniVivek Gupta
Nov 15, 2019·Current Topics in Medicinal Chemistry·Sachin KumarHimangini Bansal
Feb 23, 2021·Drug Delivery and Translational Research·Pedro FarinhaM Manuela Gaspar
May 14, 2021·Advanced Drug Delivery Reviews·Fabiana PassaroGianluca Testa
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luiz Gustavo de Almeida ChuffaRussel J Reiter
Mar 29, 2020·ACS Applied Materials & Interfaces·Jyoti AhlawatMahesh Narayan
Aug 29, 2021·Pharmaceutics·Kristin Entzian, Achim Aigner

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Methods Mentioned

BETA
chemical
Carbon Nanotubes
nanoprecipitation

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