Enhancing the efficacy of antidepressants with psychotherapy

Journal of Psychopharmacology
Timothy J Petersen

Abstract

Even after optimal treatment with and response to antidepressant medications during acute treatment of major depressive disorder, residual symptoms are common. Patients with residual symptoms are at increased risk of relapse and recurrence. Research suggests that psychotherapy may play an important role in enhancing the effects of antidepressant drug therapy and improving patients' long-term prognosis. Psychotherapy targets specific symptoms associated with relapse (e.g., guilt, hopelessness, negativity, low self-esteem) that antidepressants may not, reduces residual symptoms (e.g., irritability), improves coping skills for long-term disease management and promotes sustained, healthy cognitive changes. In addition, neuroimaging data suggest that psychotherapy and pharmacotherapy target different primary sites of the cortical-limbic pathway with differential top-down and bottom-up effects, resulting in modulation of critical common targets and facilitation of disease remission. The use of adjunctive psychotherapy in the acute phase of depression treatment appears to provide only a modest increase in response rates, although combined pharmaco-psychotherapy may prevent or delay relapse. Simultaneous application of pharmacotherapy ...Continue Reading

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Citations

May 15, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Colin A HodgkinsonDavid Goldman
Jan 10, 2012·Annual Review of Clinical Psychology·Susan Whitfield-Gabrieli, Judith M Ford
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