Enhancing the imaging and biosafety of upconversion nanoparticles through phosphonate coating

ACS Nano
Ruibin LiTian Xia

Abstract

Upconversion nanoparticles (UCNPs), which are generated by doping with rare earth (RE) metals, are increasingly used for bioimaging because of the advantages they hold over conventional fluorophores. However, because pristine RE nanoparticles (NPs) are unstable in acidic physiological fluids (e.g., lysosomes), leading to intracellular phosphate complexation with the possibility of lysosomal injury, it is important to ensure that UCNPs are safely designed. In this study, we used commercially available NaYF4:Er/Yb UCNPs to study their stability in lysosomes and simulated lysosomal fluid. We demonstrate that phosphate complexation leads to REPO4 deposition on the particle surfaces and morphological transformation. This leads to a decline in upconversion fluorescence efficiency as well as inducing pro-inflammatory effects at the cellular level and in the intact lung. In order to preserve the imaging properties of the UCNPs as well as improve their safety, we experimented with a series of phosphonate chemical moieties to passivate particle surfaces through the strong coordination of the organophosphates with RE atoms. Particle screening and physicochemical characterization revealed that ethylenediamine tetra(methylenephosphonic acid...Continue Reading

References

Jan 15, 2004·Chemical Reviews·François Auzel
Oct 10, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Anna Mondry, Rafał Janicki
Mar 18, 2008·European Journal of Radiology·Georges Saab, Ali Abu-Alfa
Aug 20, 2008·Radiology·Martin R PrinceAnthony M Valeri
May 8, 2009·Chemical Society Reviews·Feng Wang, Xiaogang Liu
May 17, 2011·Indian Journal of Dermatology·Zhitong Zou, Lin Ma
Jun 1, 2011·Angewandte Chemie·Markus Haase, Helmut Schäfer
Oct 1, 2011·Journal of the American Chemical Society·Qian LiuFuyou Li
Oct 20, 2011·Chemical Society Reviews·Jing ZhouFuyou Li
Mar 1, 2012·Journal of the American Chemical Society·Qian LiuFuyou Li
Dec 6, 2012·Journal of the American Chemical Society·Qianqian SuXiaogang Liu
Aug 6, 2013·Nature Nanotechnology·Zvicka DeutschDan Oron
Dec 18, 2013·Journal of the American Chemical Society·Pengfei DuanNobuo Kimizuka
Mar 13, 2014·Accounts of Chemical Research·Feng Wang, Xiaogang Liu
Mar 13, 2014·Advanced Materials·Chunyan LiuMingyuan Gao
Mar 22, 2014·Journal of the American Chemical Society·Yuhai ZhangXiaogang Liu
Jun 11, 2014·Advanced Materials·Swarup Kumar MajiYanli Zhao
Jun 11, 2014·Annals of the Rheumatic Diseases·Christian Schmidt-LauberJonathan Kay
Jul 11, 2014·Journal of the American Chemical Society·Filippo MarsicoFrederik R Wurm
Sep 2, 2014·Chemical Society Reviews·Anna GnachJohn A Capobianco

❮ Previous
Next ❯

Citations

Oct 30, 2015·Colloids and Surfaces. B, Biointerfaces·Yue LiuGui-Xiang Du
Apr 30, 2015·Journal of the American Chemical Society·Jing TianXiaogang Liu
Apr 19, 2016·Scientific Reports·Zefeng WangZhonggang Wang
Dec 20, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Olivija PlohlUte Resch-Genger
Feb 13, 2018·Advanced Materials·Sijie LinDaqiang Yin
Jul 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tianbo YangWanxi Zhang
Jul 9, 2017·Analytical and Bioanalytical Chemistry·Hans H Gorris, Ute Resch-Genger
May 2, 2018·Current Medicinal Chemistry·Xun ZhangMin-Xuan Sun
Mar 16, 2019·Beilstein Journal of Nanotechnology·Kartheek KattaRafael Muñoz-Espí
Jul 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jiaxiang JuanXinliang Mao
Jan 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xinyi JiangFuyou Li
Feb 2, 2021·Journal of the American Chemical Society·Dongban DuanZhibo Liu
Jan 26, 2021·Beilstein Journal of Nanotechnology·Cynthia KembuanChristina Graf
Oct 3, 2018·Ecotoxicology and Environmental Safety·Ruth HwangTian Xia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.