Enhancing the protein resistance of silicone via surface-restructuring PEO-silane amphiphiles with variable PEO length

Journal of Materials Chemistry. B, Materials for Biology and Medicine
M A RufinMelissa A Grunlan

Abstract

Silicones with superior protein resistance were produced by bulk-modification with poly(ethylene oxide) (PEO)-silane amphiphiles that demonstrated a higher capacity to restructure to the surface-water interface versus conventional non-amphiphilic PEO-silanes. The PEO-silane amphiphiles were prepared with a single siloxane tether length but variable PEO segment lengths: α-(EtO)3Si(CH2)2-oligodimethylsiloxane13-block-poly(ethylene oxide) n -OCH3 (n = 3, 8, and 16). Conventional PEO-silane analogues (n = 3, 8 and 16) as well as a siloxane tether-silane (i.e. no PEO segment) were prepared as controls. When surface-grafted onto silicon wafer, PEO-silane amphiphiles produced surfaces that were more hydrophobic and thus more adherent towards fibrinogen versus the corresponding PEO-silane. However, when blended into a silicone, PEO-silane amphiphiles exhibited rapid restructuring to the surface-water interface and excellent protein resistance whereas the PEO-silanes did not. Silicones modified with PEO-silane amphiphiles of PEO segment lengths n = 8 and 16 achieved the highest protein resistance.

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Citations

May 20, 2016·Soft Matter·C DucV Senez
Oct 25, 2016·Chemical Society Reviews·Runnan ZhangZhongyi Jiang
Jun 8, 2019·Annual Review of Chemical and Biomolecular Engineering·Amanda K Leonardi, Christopher K Ober
Aug 20, 2020·Macromolecular Bioscience·Bryan Khai D NgoMelissa A Grunlan
Nov 7, 2017·Polymer Chemistry·Melissa L HawkinsMelissa A Grunlan
Mar 1, 2017·Green Materials·Marc A RufinMelissa A Grunlan
Oct 7, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Elisa GuazzelliElisa Martinelli
Jan 19, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaobin LinGuangzhao Zhang
Dec 4, 2020·Acta Biomaterialia·Manuel Quiñones-PérezMaribella Domenech
Jul 1, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Peng HuGuangzhao Zhang
Jul 13, 2021·Comprehensive Reviews in Food Science and Food Safety·Manon SagetMaude Jimenez
Feb 6, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Peng HuGuangzhao Zhang
Jan 19, 2021·ACS Biomaterials Science & Engineering·Bryan Khai D NgoMelissa A Grunlan

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