Enhancing the Screening Efficiency of Breast Cancer by Combining Conventional Medical Imaging Examinations With Circulating Tumor Cells.

Frontiers in Oncology
Yang GaoXixiong Kang

Abstract

Ultrasound (US) and mammogram (MMG) are the two most common breast cancer (BC) screening tools. This study aimed to assess how the combination of circulating tumor cells (CTC) with US and MMG would improve the diagnostic performance. CTC detection and imaging examinations, US and MMG, were performed in 238 treatment-naive BC patients, 217 patients with benign breast diseases (BBD), and 20 healthy females. Correlations of CTC, US and MMG with patients' clinicopathological characteristics were evaluated. Diagnostic performances of CTC, US and MMG were estimated by the receiver operating characteristic curves. CTC, US and MMG could all distinguish BC patients from the control (p < 0.0001). Area under curve (AUC) of CTC, US and MMG are 0.855, 0.861 and 0.759, respectively. While US has the highest sensitivity of 0.79, CTC and MMG have the same specificity of 0.92. Notably, CTC has the highest accuracy of 0.83. Combination with CTC increases the AUC of US and MMG to 0.922 and 0.899, respectively. Combining MMG with CTC or US increases the sensitivity of MMG to 0.87, however "CTC + MMG" has a higher specificity of 0.85. "CTC + US" performs the best in BC diagnosis, followed by "CTC + MMG" and then "US + MMG". CTC can be used as a dia...Continue Reading

References

Oct 3, 2002·Journal of the National Cancer Institute·David B ThomasSteven G Self
Oct 28, 2005·The New England Journal of Medicine·Donald A BerryUNKNOWN Cancer Intervention and Surveillance Modeling Network (CISNET) Collaborators
Jul 22, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel F HayesLeon W W M Terstappen
Dec 25, 2008·Methods in Molecular Biology·Mai Brooks
Jun 3, 2009·Bosnian Journal of Basic Medical Sciences·Emine Devolli-DishaArben Kutllovci
Dec 30, 2011·Clinical Chemistry·Klaus PantelCatherine Alix-Panabières
Aug 16, 2013·Journal of the National Comprehensive Cancer Network : JNCCN·Zeynep ErogluGeorge Somlo
Apr 3, 2014·JAMA : the Journal of the American Medical Association·Lydia E Pace, Nancy L Keating
Dec 30, 2015·Journal of the National Cancer Institute·Wendie A BergEtta D Pisano
Jan 27, 2016·Molecular Oncology·Francois-Clement BidardJean-Yves Pierga
Feb 3, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Elizabeth S McDonaldGary M Freedman
Dec 14, 2016·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Jong-Myon Bae, Eun Hee Kim
Jan 9, 2019·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 2, 2019·Primary Care·Veronica JordanDonna Prill
Jun 19, 2019·Nature Genetics·Zheng HuChristina Curtis

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