PMID: 6400198Jan 1, 1984Paper

Enhancing the self-repairing potential of the CNS after injury

Central Nervous System Trauma : Journal of the American Paralysis Association
C W CotmanR B Gibbs

Abstract

Embryonic CNS tissues can now be successfully transplanted into most regions of the CNS in neonate, adult, or aged host animals. The transplants generally project to their correct target areas in the host brain. However, transplants appear to receive only partial innervation by host fibers. Replacement of lost host neurons by transplants has proven to be functionally most successful in the cases of neurosecretory, monoaminergic, or cholinergic neurons. Their success probably depends on their ability to deliver the proper neurotransmitter (and perhaps trophic factors) close to their targets rather than on their capacity to reestablish all lost connections. Efforts to achieve complete integration of the transplants will probably require interventive strategies to guide the natural repair response of CNS tissue. Survival and outgrowth of the transplants can be promoted by taking advantage of the natural increase of neurotrophic factors in response to injury. Neurotrophic factors and substrate guidance factors, once purified and completely characterized, promise to be powerful new therapeutic agents for enhancing the survival and regrowth of the injured CNS.

References

Jul 20, 1979·Brain Research·A BjörklundU Stenevi
Jul 30, 1976·Science·J DiamondL Macintyre
Jan 1, 1984·Annual Review of Neuroscience·D K Berg
Jan 13, 1980·Brain Research·D Goldowitz, C W Cotman
Jan 1, 1982·Annual Review of Psychology·C W Cotman, M Nieto-Sampedro
Jul 1, 1981·Physiological Reviews·C W CotmanE W Harris
Jan 28, 1982·Brain Research·G LundborgS Varon
Nov 18, 1982·Brain Research·S B DunnettA Björklund
Jul 3, 1980·Nature·T EbendalK O Hedlund
May 1, 1980·Brain Research Bulletin·E R LewisC W Cotman
Dec 19, 1980·Science·D GashC D Sladek
Jul 1, 1940·Journal of Neurology and Psychiatry·W E Clark

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