Enhancing the Therapeutic Potential of Olfactory Ensheathing Cells in Spinal Cord Repair Using Neurotrophins

Cell Transplantation
A A WrightJ A Ekberg

Abstract

Autologous olfactory ensheathing cell (OEC) transplantation is a promising therapy for spinal cord injury; however, the efficacy varies between trials in both animals and humans. The main reason for this variability is that the purity and phenotype of the transplanted cells differs between studies. OECs are susceptible to modulation with neurotrophic factors, and thus, neurotrophins can be used to manipulate the transplanted cells into an optimal, consistent phenotype. OEC transplantation can be divided into 3 phases: (1) cell preparation, (2) cell administration, and (3) continuous support to the transplanted cells in situ. The ideal behaviour of OECs differs between these 3 phases; in the cell preparation phase, rapid cell expansion is desirable to decrease the time between damage and transplantation. In the cell administration phase, OEC survival and integration at the injury site, in particular migration into the glial scar, are the most critical factors, along with OEC-mediated phagocytosis of cellular debris. Finally, continuous support needs to be provided to the transplantation site to promote survival of both transplanted cells and endogenous cells within injury site and to promote long-term integration of the transpla...Continue Reading

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Citations

Jun 17, 2020·Biomedical Materials·Mariah SarwatAurelien Forget
Feb 15, 2020·Journal of Neurotrauma·Aaron D GilmourJames A St John
Nov 19, 2020·Stem Cells International·Liansheng GaoGao Chen
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Lynn NazarethJenny Ekberg
May 11, 2021·Journal of Molecular Neuroscience : MN·Yi-Sha GuoXia Bi
May 23, 2021·Scientific Reports·Indra N ChoudhuryJenny A K Ekberg
Jun 15, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yu-Ting TsengJenny Ekberg
Dec 2, 2021·Stem Cells and Development·Olga V StepanovaVladimir P Chekhonin

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Methods Mentioned

BETA
biopsy
OECs
GTPase

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