Enhancing Tumor Cell Response to Multidrug Resistance with pH-Sensitive Quercetin and Doxorubicin Conjugated Multifunctional Nanoparticles

Colloids and Surfaces. B, Biointerfaces
Cenk Daglioglu

Abstract

Classical chemotherapy uses chemotherapeutic agents as a mainstay of anticancer treatment. However, the development of multidrug resistance to chemotherapy limits the effectiveness of current cancer treatment. Nanosized bioconjugates combining a chemotherapeutic agent with a pharmacological approach may improve the curative effect of chemotherapeutic agents. Herein I addressed this issue by describing the synthesis, and testing of, pH-responsive Fe3O4@SiO2(FITC)-BTN/QUR/DOX multifunctional nanoparticles. The particles were designed to modulate resistance-mediating factors and to potentiate the efficacy of DOX against chemoresistance. The physicochemical properties of the nanoparticles were characterized based on the combination of several techniques: dynamic light scattering (DLS), zeta-potential measurement, Fourier transform infrared spectroscopy (FTIR), electron microscopy techniques (SEM and STEM with EDX) and an in vitro pH-dependent release study. Cellular uptake and cytotoxicity experiments demonstrated enhanced intracellular delivery and retention of nanoparticles in the cytoplasm and efficient reduction of cancer cell viability in drug-resistant lung carcinoma A549/DOX cell lines. This did not affect internalization an...Continue Reading

Citations

Aug 15, 2017·Journal of Drug Targeting·Juan LiRongmei Wang
Feb 15, 2020·The Journal of International Medical Research·Xiaojun SunGuobiao Yang
Feb 16, 2020·BMC Pharmacology & Toxicology·Xiangyan LiuMingmei Liao
Oct 7, 2019·Drug Discovery Today·Mohammad NorouziFatemeh Atyabi
Jun 22, 2021·Food & Function·Xinlong ZangXuehong Chen
Oct 31, 2021·Journal of Cosmetic Dermatology·Alessandro LeoneIrene Fusco

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