Enjoyment of Spicy Flavor Enhances Central Salty-Taste Perception and Reduces Salt Intake and Blood Pressure

Hypertension
Qiang LiZhiming Zhu

Abstract

High salt intake is a major risk factor for hypertension and is associated with cardiovascular events. Most countries exhibit a traditionally high salt intake; thus, identification of an optimal strategy for salt reduction at the population level may have a major impact on public health. In this multicenter, random-order, double-blind observational and interventional study, subjects with a high spice preference had a lower salt intake and blood pressure than subjects who disliked spicy food. The enjoyment of spicy flavor enhanced salt sensitivity and reduced salt preference. Salt intake and salt preference were related to the regional metabolic activity in the insula and orbitofrontal cortex (OFC) of participants. Administration of capsaicin-the major spicy component of chili pepper-enhanced the insula and OFC metabolic activity in response to high-salt stimuli, which reversed the salt intensity-dependent differences in the metabolism of the insula and OFC. In animal study, OFC activity was closely associated with salt preference, and salty-taste information processed in the OFC was affected in the presence of capsaicin. Thus, interventions related to this region may alter the salt preference in mice through fiber fluorometry a...Continue Reading

References

Mar 22, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T Q DuongS G Kim
Mar 15, 2001·Journal of Neurophysiology·J O'DohertyF McGlone
May 12, 2004·Brain and Cognition·Edmund T Rolls
Oct 21, 2006·Nature Reviews. Neuroscience·Sidney A SimonMiguel A L Nicolelis
Mar 9, 2007·The Proceedings of the Nutrition Society·Edmund T Rolls
Sep 25, 2008·Current Biology : CB·Nils DamannBernd Nilius
May 14, 2009·Cerebral Cortex·R ElliottJ F W Deakin
Nov 26, 2009·BMJ : British Medical Journal·Pasquale StrazzulloFrancesco P Cappuccio
Jan 22, 2010·The New England Journal of Medicine·Kirsten Bibbins-DomingoLee Goldman
Jan 5, 2011·Advances and Technical Standards in Neurosurgery·A J Oliveira-MaiaM A L Nicolelis
Sep 13, 2011·Cardiovascular Research·Liqun MaMartin Tepel
Oct 8, 2011·EMBO Reports·Bernd Nilius, Giovanni Appendino
Nov 24, 2011·JAMA : the Journal of the American Medical Association·Martin J O'DonnellRoland E Schmieder
Oct 16, 2012·Lancet·Robert BeagleholeK Srinath Reddy
Mar 29, 2013·The New England Journal of Medicine·Theodore A KotchenEdward D Frohlich
Apr 23, 2013·Reviews of Physiology, Biochemistry and Pharmacology·Bernd Nilius, Giovanni Appendino
Dec 25, 2013·BMJ Open·John PowlesUNKNOWN Global Burden of Diseases Nutrition and Chronic Diseases Expert Group (NutriCoDE)
Jan 11, 2014·Journal of Cognitive Neuroscience·Erin L Rich, Jonathan D Wallis
Aug 15, 2014·The New England Journal of Medicine·Martin O'DonnellUNKNOWN PURE Investigators
Oct 3, 2014·Cold Spring Harbor Protocols·Helmuth AdelsbergerArthur Konnerth
Aug 6, 2015·BMJ : British Medical Journal·Jun LvUNKNOWN China Kadoorie Biobank Collaborative Group
Feb 18, 2016·JAMA : the Journal of the American Medical Association·David B HipgraveYongning Wu
Mar 15, 2016·JAMA Internal Medicine·Sarah LewingtonUNKNOWN China Kadoorie Biobank Consortium

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Citations

Nov 2, 2017·Hypertension·Richard David Wainford
Jul 14, 2018·Journal of Hypertension·Shahabeddin RezaeiFarshad Farzadfar
Jan 9, 2019·Journal of Cellular Physiology·Peng GaoZhiming Zhu
Sep 14, 2019·Clinical and Experimental Hypertension : CHE·Yukiko SegawaNobutaka Kurihara
Jul 12, 2019·Journal of the American Heart Association·Monique TanGraham A MacGregor
Nov 20, 2020·International Journal of Food Sciences and Nutrition·Qiaorui WenLiming Li
Nov 2, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Mohammad Reza AminiSakineh Shab-Bidar

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