Enkephalin, PPE mRNA, and PTS-1 in alcohol withdrawal seizure-prone and -resistant mice

Alcohol
S R PlotkinA J Kastin

Abstract

Inbred animal strains provide an opportunity to study genetic factors in alcoholism in the absence of environmental factors. Although the concentration of methionine enkephalin (Met-enkephalin) in whole brain has been implicated in the consumption of ethanol, it has not been studied in the brains of alcohol withdrawal seizure-prone (WSP) and withdrawal seizure-resistant (WSR) mice. We compared these concentrations with the levels of preproenkephalin (PPE) mRNA and with the activity of peptide transport system-1 (PTS-1), a brain-to-blood transport system for Met-enkephalin that is affected by ethanol. The concentrations of Met-enkephalin were significantly greater in WSP mice than in WSR mice, whereas synthesis of Met-enkephalin, as reflected by PPE mRNA levels, and transport out of the brain by PTS-1 was not different. These results support a direct link between elevated concentrations of Met-enkephalin in whole brain and proneness to withdrawal-induced seizures. We suggest that the inverse relationship between the consumption of ethanol and proneness to seizures in inbred mice can be explained through their opposite relationships to Met-enkephalin.

References

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Jan 1, 1996·Alcohol·C P O'BrienJ R Volpicelli

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Citations

Aug 14, 2012·Psychopharmacology·Lara S HwaKlaus A Miczek
Apr 28, 2001·Pharmacology, Biochemistry, and Behavior·S R PlotkinA J Kastin
Mar 4, 2000·Peptides·A L VaccarinoA J Kastin
Jun 29, 2000·Neurochemistry International·A S Beadles-BohlingK M Wiren

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