PMID: 3072969Nov 1, 1988Paper

Enkephalinase inhibition and precursor amino acid loading improves inpatient treatment of alcohol and polydrug abusers: double-blind placebo-controlled study of the nutritional adjunct SAAVE

K BlumL Cataldie


We investigated the effects of the amino acid and vitamin mixture SAAVE in inpatient, chemically-dependent subjects to evaluate the role of neurotransmitters in facilitating recovery and adjustment to a detoxified, sober state. SAAVE is formulated from amino acids that are precursors for neurotransmitters and neuromodulators thought to be involved in alcohol and drug seeking behavior. In a double-blind, placebo-controlled, randomized study of 62 alcoholics and polydrug abusers, SAAVE patients had a significantly reduced stress response as measured by the skin conductance level (SCL), and significantly improved Physical Scores and BESS Scores (behavioral, emotional, social and spiritual). After detoxification there was a six-fold decrease in AMA rates when comparing SAAVE vs. placebo groups. In this inpatient treatment experience SAAVE facilitated the rate of recovery and allowed patients to respond more fully and more quickly to the behavioral goals of the program, for example as measured by the BESS Score. The use of SAAVE to achieve enkephalinase inhibition and precursor amino acid loading in the acute inpatient treatment environment provides the practitioner with the potential ability to restore the neurochemical changes inh...Continue Reading


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May 1, 1979·Drug and Alcohol Dependence·P L Hoffman, B Tabakoff
Jul 1, 1975·Journal of Neurochemistry·I A SytinskyN N Konovalova
Jan 1, 1987·The American Journal of Drug and Alcohol Abuse·M C Trachtenberg, K Blum
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A GordonI Diamond
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·I DiamondA Gordon
Jan 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·J FagiusB E Wiholm
Jan 21, 1988·The New England Journal of Medicine·B TabakoffF De Leon-Jones
Jan 1, 1985·Brain & Development·J M Allen, S R Bloom
Apr 1, 1985·Journal of Neurochemistry·T SaitoB Tabakoff
Dec 15, 1985·Biochemical Pharmacology·R A Rabin
Nov 1, 1985·Archives of General Psychiatry·M A Schuckit
Feb 4, 1974·JAMA : the Journal of the American Medical Association·A KalesJ D Kales
Apr 30, 1973·Annals of the New York Academy of Sciences·R D Myers, G E Martin
Apr 1, 1974·Japanese Journal of Pharmacology·Y Yamanaka, S Kono
Feb 1, 1982·The Journal of Pharmacy and Pharmacology·A K Ho, N Rossi
Feb 1, 1984·Postgraduate Medicine·M A Schuckit
Dec 1, 1984·Pharmacology, Biochemistry, and Behavior·W A Banks, A J Kastin
Mar 1, 1984·Clinical Pharmacology and Therapeutics·C A NaranjoK Sykora
Sep 1, 1982·The Journal of Clinical Endocrinology and Metabolism·A R GenazzaniF Savoldi
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·K BlumJ E Wallace
Jul 1, 1980·Alcoholism, Clinical and Experimental Research·R W PelhamT L Munsat
Nov 19, 1981·The New England Journal of Medicine·E M SellersJ E Peachey


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Jul 1, 1988·Journal of Psychoactive Drugs·D E Horne
Apr 1, 1990·Journal of Psychoactive Drugs·R J BrownM C Trachtenberg
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