Enkephalinergic afferents of the centromedial amygdala in the rat

The Journal of Comparative Neurology
Jean-François PoulinG Drolet

Abstract

The connectivity of the amygdaloid complex has been extensively explored with both anterograde and retrograde tracers. Even though the afferents of the centromedial amygdala [comprising the central (CEA) and medial (MEA) amygdaloid nuclei] are well established, relatively little is known about the neuropeptide phenotype of these connections. In this study, we first examined the distribution of mu-opioid receptor (MOR) and delta-opioid receptor (DOR) in the amygdala via in situ hybridization and immunohistochemistry. We then investigated the distribution of Met-enkephalin (ENK) and Leu-ENK fibers with immunohistochemistry and examined the distribution of preproenkephalin mRNA in the amygdala by using in situ hybridization. Finally, we examined the ENK projections to the CEA and MEA by using stereotaxic injections of the retrograde tracer cholera toxin subunit B or fluorogold revealed by immunohistochemistry combined with in situ hybridization to identify ENKergic neurons. Our results indicate that the centromedial amygdala receives ENK afferents, as indicated by the presence of MOR, DOR, and ENK fibers in the CEA and MEA, originating primarily from the bed nucleus of the stria terminalis (BST) and from other amygdaloid nuclei. T...Continue Reading

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Citations

Jan 25, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marlene A Wilson, Lorain Junor
Jul 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·K M WassumB W Balleine
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Apr 21, 2012·Brain Research·Elizabeth Palomares-CastilloMiguel Pérez de la Mora
Jul 9, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jean-François PoulinGuy Drolet
May 26, 2009·Behavioural Brain Research·Ameneh RezayofMohammad-Reza Zarrindast
Jan 20, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Alicia CabralVanessa M Castilho
Jul 1, 2008·The European Journal of Neuroscience·K BefortB L Kieffer
Dec 19, 2007·The Journal of Comparative Neurology·Jean-François PoulinGuy Drolet
Feb 2, 2013·The European Journal of Neuroscience·Jean-François PoulinGuy Drolet
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Oct 5, 2013·Stress : the International Journal on the Biology of Stress·Jean-François PoulinGuy Drolet
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