PMID: 6168330Sep 7, 1981Paper

Enkephalins, substance P, bradykinin and angiotensin II: differential sites of action on the hypothalamo-neurohypophysial system

Brain Research
A J BaertschiJ J Dreifuss

Abstract

To test the hypothesis that enkephalins, substance P, bradykinin and angiotensin II could act as neurohumoral modulators of hypothalamic function, these peptides (0.01-20 microgram) were injected into the general circulation of anesthetized rats, and changes in hypothalamo-neurohypophysial activity were determined by continuously monitoring the amplitude of antidromic compound action potentials (CAP) in the hypothalamo-hypophysial tract. A decrease of CAP amplitude was taken to indicate an increase of orthodromic impulse traffic. All peptides elicited a CAP decrease. On a molar basis when injected i.v., the enkephalin analog FK 33-824 was the most effective substance, followed by substance P, Leu-enkephalin and angiotensin II. Enkephalins and substance P injected through the internal carotid artery, were 2-5 times more effective than when injected i.v., whereas bradykinin was most effective when it reached the brain through a vertebral route. Angiotensin II produced the same CAP decrease irrespective of the route of administration and, in contradistinction to the other peptides, its effect was not abolished by stalk section. Tachyphylaxis and reversibility with naloxone was observed only for the enkephalins. The data suggest th...Continue Reading

References

Jul 20, 1979·Science·A I Faden, J W Holaday
Mar 1, 1978·British Journal of Pharmacology·G W BissetW Feldberg
Feb 1, 1977·The Journal of Physiology·E Castro de Souza, M Rocha E Silva
Nov 5, 1976·Brain Research·M J BrownsteinS E Leeman
Aug 11, 1975·British Journal of Pharmacology·W FeldbergM Rocha e Silva
Oct 6, 1971·Nature: New Biology·R A Nicoll, J L Barker
Sep 5, 1974·The New England Journal of Medicine·R W Colman
Jan 17, 1980·Nature·V Clement-JonesG M Besser
Jun 6, 1931·The Journal of Physiology·U S V Euler, J H Gaddum

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Citations

May 21, 1982·European Journal of Pharmacology·W KnepelD K Meyer
Oct 1, 1983·Pharmacology, Biochemistry, and Behavior·K SchlesingerT N Chase
Nov 1, 1982·Peptides·G A OlsonD H Coy
Sep 1, 1983·Behavioral and Neural Biology·K SchlesingerT N Chase
Aug 23, 2002·Pharmacology & Therapeutics·Bilkish CassimKanti Bhoola
Feb 1, 1987·The Proceedings of the Nutrition Society·B I Posner
Mar 1, 1982·The Journal of Clinical Investigation·S Ishikawa, R W Schrier
Jun 1, 1988·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M E Valle-SotoA Perez-Casas
Feb 1, 1988·Hypertension·L F CarbonellA G Scicli
May 1, 1995·The American Journal of Physiology·C Yang, W H Hsu

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