Abstract
Enlarged substantia nigra hyperechogenicity (SN+) assessed by transcranial sonography (TCS) may be associated with Parkinson's disease (PD) risk markers such as impaired motor performance and hyposmia. The aim of this multicenter cross-sectional study was to define the association between SN+ and these risk markers in a large population older than 50 years without the diagnosis of PD. In three centers (Tuebingen, Homburg, and Innsbruck), 1,839 individuals were examined. The echostatus of the SN was assessed by TCS, motor performance by the Unified Parkinson's Disease Rating Scale (UPDRS) motor score, and olfactory function with Sniffin' Sticks. From the 1,603 subjects included in the analysis, 16.2% were SN+, 23.0% scored above zero in the UPDRS motor section, and 28.0% were hyposmic as defined by less than 75% correctly classified Sniffin' Sticks. SN+ was associated with a UPDRS motor score above zero (OR 1.45, 95% CI 1.08-1.96) and with a lower odor identification capability (OR 1.48, 95% CI 1.12-1.96). The combination of these two features (OR 1.98, 95% CI 1.25-3.15) and UPDRS motor scores >or=3 lead to higher OR. It is concluded that SN+, impaired motor performance, and hyposmia are frequently observed in the elderly and in...Continue Reading
References
Jan 1, 1992·Movement Disorders : Official Journal of the Movement Disorder Society·A J Lees
Oct 1, 1991·Brain : a Journal of Neurology·J M Fearnley, A J Lees
Jun 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·W R Gibb, A J Lees
Nov 1, 1994·Annals of Neurology·F J VingerhoetsD B Calne
Nov 1, 1993·Neurology·M RichardsR Mayeux
Aug 26, 1999·Ultrasound in Medicine & Biology·D BergG Becker
Sep 25, 1999·Neurology·D BergK W Lange
Jan 10, 2001·Neurology·D BergG Becker
Sep 22, 2001·Biological Psychiatry·D BergG Becker
Sep 25, 2001·Journal of Neurology·D BergG Becker
Oct 20, 2001·The Annals of Otology, Rhinology, and Laryngology·T HummelG Kobal
Jun 12, 2002·Archives of Neurology·Daniela BergGeorg Becker
Jul 19, 2002·The New England Journal of Medicine·Stefan KiechlDavid A Schwartz
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Apr 3, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher Hawkes
Jul 9, 2003·Neurology·Elan D LouisRichard Mayeux
Aug 5, 2004·Annals of Neurology·Mirthe M PonsenHenk W Berendse
Aug 18, 2004·Archives of Neurology·Elan D LouisRichard Mayeux
Sep 25, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Ulrike SommerHeinz Reichmann
Oct 16, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Daniela BergGeorg Becker
Mar 16, 2005·Archives of Neurology·Ruediger HilkerWolf-Dieter Heiss
Jan 13, 2006·Archives of Neurology·Lonneke M L de LauMonique M B Breteler
Feb 14, 2006·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·D BergU Walter
May 24, 2006·Neurology·Werner Poewe
Oct 24, 2006·Parkinsonism & Related Disorders·Petra Ruprecht-DörflerDaniela Berg
Dec 26, 2006·Ultrasound in Medicine & Biology·Uwe WalterDaniela Berg
Jan 18, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Heike StocknerWerner Poewe
Dec 11, 2007·Annals of Neurology·G Webster RossLon R White
Apr 9, 2008·Lancet Neurology·Alexandra GaenslenDaniela Berg
Oct 1, 2008·Cephalalgia : an International Journal of Headache·J SchwaigerJ Willeit
Apr 9, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Mirthe M PonsenHenk W Berendse
Aug 1, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Heike StocknerUNKNOWN SINBAR (Sleep Innsbruck Barcelona) Group
Citations
Jul 9, 2013·Der Nervenarzt·B MollenhauerE Kalbe
Jan 7, 2011·Journal of Neural Transmission·I Liepelt-ScarfoneD Berg
Aug 3, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·D BergUNKNOWN PRIPS study group
Mar 30, 2012·PloS One·Walter MaetzlerLorenzo Chiari
Oct 16, 2010·Biomarkers in Medicine·Mark FrasierTodd Sherer
Mar 8, 2014·Brain Research·Tuan-Zhi ChenYi-Feng Du
Feb 5, 2016·Parkinsonism & Related Disorders·Hai-Yan ZhouSheng-Di Chen
Sep 24, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Jost-Julian RumpfJoseph Classen
May 8, 2013·Sleep Medicine·Masayuki Miyamoto, Tomoyuki Miyamoto
Jan 27, 2012·Archives of Gerontology and Geriatrics·Joong-Seok KimKwang-Soo Lee
Oct 29, 2011·Sleep Medicine·Masayuki MiyamotoKoichi Hirata
Nov 5, 2015·Journal of Neurology·Inga Liepelt-ScarfoneDaniela Berg
Nov 2, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Jost-Julian RumpfJoseph Classen
Mar 23, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Walter Maetzler, Jeffrey M Hausdorff
Apr 13, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Anthony E Lang
Apr 18, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Jana GodauKlaus Seppi
Apr 18, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Daniela BergWerner Poewe
Nov 6, 2013·Journal of Neurology·Stefanie LercheDaniela Berg
Nov 12, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Alex IranzoWerner Poewe
Dec 23, 2011·Parkinsonism & Related Disorders·Daniela Berg
Sep 6, 2011·Neurobiology of Disease·Suzana GispertGeorg Auburger
Nov 9, 2011·The International Journal of Neuroscience·Robert A Hauser
Apr 30, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Maartje LouterInga Liepelt-Scarfone
May 27, 2015·Current Neurology and Neuroscience Reports·Andrea PilottoDaniela Berg
Nov 22, 2015·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Toomas ToomsooPille Taba
Jun 16, 2017·Neurology·Alex IranzoUNKNOWN SINBAR (Sleep Innsbruck Barcelona) group
Sep 12, 2015·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·E Yu FedotovaS N Illarioshkin
Oct 31, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Jost-Julian RumpfJoseph Classen
Sep 6, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·I Liepelt-ScarfoneD Berg
Aug 21, 2017·Movement Disorders Clinical Practice·Marina PicilloMaria Teresa Pellecchia
Nov 23, 2016·Journal of the Neurological Sciences·Christoph PauschStefanie Behnke
May 4, 2021·Journal of Parkinson's Disease·Katherine C HughesAlberto Ascherio