Enlightening advances in polymer bioconjugate chemistry: light-based techniques for grafting to and from biomacromolecules.

Chemical Science
Rebecca A OlsonBrent S Sumerlin

Abstract

Photochemistry has revolutionized the field of polymer-biomacromolecule conjugation. Ligation reactions necessitate biologically benign conditions, and photons have a significant energy advantage over what is available thermally at ambient temperature, allowing for rapid and unique reactivity. Photochemical reactions also afford many degrees of control, specifically, spatio-temporal control, light source tunability, and increased oxygen tolerance. Light-initiated polymerizations, in particular photo-atom-transfer radical polymerization (photo-ATRP) and photoinduced electron/energy transfer reversible addition-fragmentation chain transfer polymerization (PET-RAFT), have been used for grafting from proteins, DNA, and cells. Additionally, the spatio-temporal control inherent to light-mediated chemistry has been utilized for grafting biomolecules to hydrogel networks for many applications, such as 3-D cell culture. While photopolymerization has clear advantages, there are factors that require careful consideration in order to obtain optimal control. These factors include the photocatalyst system, light intensity, and wavelength. This Perspective aims to discuss recent advances of photochemistry for polymer biomacromolecule conjugat...Continue Reading

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Citations

Oct 27, 2020·Chemical Reviews·Gangam Srikanth Kumar, Qing Lin
Jul 14, 2020·Macromolecular Rapid Communications·Nathan R B Boase
Jun 15, 2021·Chemical Science·Grzegorz SzczepaniakKrzysztof Matyjaszewski
Sep 22, 2020·Chemical Science·Kevin M BurridgeRichard C Page
Mar 23, 2021·Accounts of Chemical Research·Grzegorz SzczepaniakKrzysztof Matyjaszewski
May 4, 2021·Chemical Reviews·Qiao SongSébastien Perrier

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Methods Mentioned

BETA
RAFT
selectively
irradiate
dynamic exchange

Software Mentioned

eATRP

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