ENLIST 1: An International Multi-centre Cross-sectional Study of the Clinical Features of Erythema Nodosum Leprosum

PLoS Neglected Tropical Diseases
Stephen L WalkerErythema Nodosum Leprosum International STudy Group

Abstract

Erythema nodosum leprosum (ENL) is a severe multisystem immune mediated complication of borderline lepromatous leprosy and lepromatous leprosy. ENL is associated with skin lesions, neuritis, arthritis, dactylitis, eye inflammation, osteitis, orchitis, lymphadenitis and nephritis. The treatment of ENL requires immunosuppression, which is often required for prolonged periods of time and may lead to serious adverse effects. ENL and its treatment is associated with increased mortality and economic hardship. Improved, evidence-based treatments for ENL are needed; however, defining the severity of ENL and outcome measures for treatment studies is difficult because of the multiple organ systems involved. A cross-sectional study was performed, by the members of the Erythema Nodosum Leprosum International STudy (ENLIST) Group, of patients with ENL attending seven leprosy referral centres in Brazil, Ethiopia, India, Nepal, the Philippines and the United Kingdom. We systematically documented the clinical features and type of ENL, its severity and the drugs used to treat it. Patients with chronic ENL were more likely to be assessed as having severe ENL. Pain, the most frequent symptom, assessed using a semi-quantitative scale was significa...Continue Reading

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Citations

Mar 15, 2014·PLoS Neglected Tropical Diseases·Stephen L WalkerSaba M Lambert
Jan 16, 2015·PLoS Neglected Tropical Diseases·David J ChandlerDiana N J Lockwood
Aug 25, 2016·PLoS Neglected Tropical Diseases·Veronica SchmitzEuzenir Nunes Sarno
Jul 4, 2017·PLoS Neglected Tropical Diseases·Stephen L WalkerUNKNOWN Erythema Nodosum Leprosum International STudy Group
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Methods Mentioned

BETA
biopsy

Software Mentioned

ENLIST
Excel
Stata

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