ENO1 Overexpression in Pancreatic Cancer Patients and Its Clinical and Diagnostic Significance

Gastroenterology Research and Practice
Hang YinHai-Lin Liu

Abstract

We investigated in this study the expression of ENO1 in tissues and plasma of PDAC patients to evaluate its clinicopathological and diagnostic significance. ENO1 protein expression was detected in tissue microarray of human PDAC and adjacent noncancer tissues. Electrochemiluminescence immunoassay and amplified luminescent proximity homogeneous assay (AlphaLISA) were performed to measure CA19-9 and ENO1 concentration in plasma from PDAC patients and healthy controls. We demonstrated that ENO1 overexpression is positively correlated with clinical stage, lymph node metastasis, and poor prognosis of PDAC; ENO1 may function as a hopeful candidate diagnostic marker in combination with CA19-9 in PDAC diagnosis.

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Citations

Jan 15, 2020·Cancer Informatics·Po-Ming ChenEn-Pei Isabel Chiang
Feb 16, 2021·Frontiers in Genetics·Frankis A AlmaguelCarlos A Casiano
Feb 15, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Laura TorresanoJosé M Cuezva
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Claudia CurcioFrancesco Novelli
May 11, 2021·Frontiers in Cell and Developmental Biology·Yang LiuShaoyan Liu
Jun 17, 2021·Journal of Agricultural and Food Chemistry·Asifa KhanMohammad Askandar Iqbal

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Methods Mentioned

BETA
AlphaLISA
enzyme-linked immunosorbent adsorption

Software Mentioned

AlphaLISA
SPSS statistic

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