eNose breath prints as a surrogate biomarker for classifying patients with asthma by atopy.

The Journal of Allergy and Clinical Immunology
Mahmoud I Abdel-AzizAmsterdam UMC Breath Research Group

Abstract

Electronic noses (eNoses) are emerging point-of-care tools that may help in the subphenotyping of chronic respiratory diseases such as asthma. We aimed to investigate whether eNoses can classify atopy in pediatric and adult patients with asthma. Participants with asthma and/or wheezing from 4 independent cohorts were included; BreathCloud participants (n = 429), Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes adults (n = 96), Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes pediatric participants (n = 100), and Pharmacogenetics of Asthma Medication in Children: Medication with Anti-Inflammatory Effects 2 participants (n = 30). Atopy was defined as a positive skin prick test result (≥3 mm) and/or a positive specific IgE level (≥0.35 kU/L) for common allergens. Exhaled breath profiles were measured by using either an integrated eNose platform or the SpiroNose. Data were divided into 2 training and 2 validation sets according to the technology used. Supervised data analysis involved the use of 3 different machine learning algorithms to classify patients with atopic versus nonatopic asthma with reporting of areas under the receiver operating characteristic curves as a measure of model performance....Continue Reading

Citations

Sep 19, 2021·Respiratory Research·I G van der SarC C Moor
Sep 25, 2021·Clinical Chemistry·Daniel S HermanThomas J S Durant
Oct 17, 2021·The Journal of Allergy and Clinical Immunology·Rachel L MillerKasey Strothman

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