Feb 1, 1989

Enoxacin: a new fluoroquinolone

Clinical Pharmacy
L A JaberM J Rybak


The chemistry, mechanisms of action and resistance, pharmacokinetics, antimicrobial spectrum, clinical efficacy, adverse effects, and drug interactions of enoxacin are reviewed. Enoxacin is a new fluoroquinolone compound structurally related to nalidixic acid. Its antimicrobial spectrum and activity are comparable to those of the fluoroquinolones norfloxacin and ciprofloxacin. It has a broad spectrum of activity against gram-negative and gram-positive microorganisms, but like the other fluoroquinolones it is less active against gram-positive micro-organisms. Anaerobic organisms are generally resistant to enoxacin. It is rapidly and nearly completely absorbed after oral administration and is distributed widely in body fluids and tissues. The drug is predominantly excreted via the kidney, with a relatively long serum elimination half-life of approximately five hours. Serum and urinary concentration of enoxacin exceed the minimum inhibitory concentrations for most gram-negative and many gram-positive pathogens. Clinical trials have shown enoxacin to be effective for the treatment of gonorrhea, cystitis, complicated urinary-tract infections, and skin and skin structure infections. There is some evidence that enoxacin may be useful ...Continue Reading

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Mentioned in this Paper

Urinary Tract Infection
Drug Interactions
CNS Disorder
Clinical Trials
Drug Toxicity
Bacterial Infections

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