Enoxaparin dosing after discharge from US hospitals in patients with total knee replacement

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Robert WrightEduardo Ramacciotti

Abstract

Prophylaxis for venous thromboembolism after total knee replacement (TKR) is standard of care. Two enoxaparin regimens are approved for thromboprophylaxis, one in the United States (30 mg twice daily [bid]) and another in the rest of the world (40 mg once daily [qd]). Data on frequency of utilization of these 2 regimens at discharge from US hospitals after TKR are not available. We conducted a retrospective/descriptive analysis of the PharMetrics claims database to estimate the frequency of utilization of enoxaparin 40 mg qd compared to 30 mg bid after discharge for TKR from US hospitals. Of the 44 552 TKR patients identified, 7198 had an outpatient claim for enoxaparin within 14 days postoperatively. The 40 mg strength of enoxaparin was prescribed more commonly (~51%) than the 30 mg strength (~46%). Enoxaparin 40 mg qd is prescribed in approximately the same proportion of patients as the current Food and Drug Administration-approved regimen of 30 mg bid.

References

Aug 17, 2005·Journal of Thrombosis and Haemostasis : JTH·J A Heit
Jun 27, 2008·The New England Journal of Medicine·Michael R LassenUNKNOWN RECORD3 Investigators
Aug 16, 2008·Clinical Orthopaedics and Related Research·Stavros G MemtsoudisThomas P Sculco
Aug 7, 2009·The New England Journal of Medicine·Michael Rud LassenRonald J Portman

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Citations

Oct 19, 2016·The Journal of Arthroplasty·Kara N RadzakCass K Nakasone
May 29, 2021·Quality Management in Health Care·Douglas TremblayWilliam K Oh

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Software Mentioned

PharMetrics

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