ENPP1 121Q functional variant enhances susceptibility to coronary artery disease in South Indian patients with type 2 diabetes mellitus

Molecular and Cellular Biochemistry
S SumiC C Kartha

Abstract

Insulin resistance is associated with endothelial dysfunction and ensuing cardiovascular diseases in type 2 diabetes mellitus (T2DM) patients. ENPP1 is a key modulator of insulin signaling and its polymorphism, K121Q, increases the potency to competitively inhibit insulin receptor binding. We investigated the association of ENPP1 121Q variant with coronary artery disease (CAD) in patients with and without T2DM in South Indian population. Our study was conducted in 913 subjects: 198 patients with CAD, 284 patients in whom T2DM and CAD co-exists, 160 patients with T2DM and no CAD history, and 271 healthy volunteers. Genotyping was performed using PCR-RFLP and PCR-DNA sequencing. Genotype frequency of ENPP1 121Q was higher in disease groups compared to healthy subjects (p < 0.05). T2DM patients who carried polymorphic AC/CC genotypes were at 12.8-fold enhanced risk to CAD (95% CI 4.97-37.18, p < 0.01). Moreover we observed that 121Q, both in heterozygous and homozygous polymorphic states, was a risk factor for CAD without diabetes (OR 4.15, p < 0.01). 121Q variant was associated with T2DM patients with no CAD history too, but the risk was statistically insignificant after multivariate logistic regression analysis (OR 2.32, p > 0.0...Continue Reading

References

Aug 31, 2001·Journal of the American College of Cardiology·V MohanUNKNOWN Chennai Urban Population Study (CUPS No.5)
Mar 29, 2005·Diabetes·Nicola AbateViswanathan Mohan
Feb 20, 2010·Journal of Diabetes Science and Technology·Viswanathan MohanRajendra Pradeepa
Sep 8, 2010·Molecular and Cellular Biochemistry·Jasvinder Singh BhattiR Tewari
Jan 11, 2012·Arquivos brasileiros de endocrinologia e metabologia·Denise Alves SorticaLuis Henrique Canani
Sep 14, 2012·The Review of Diabetic Studies : RDS·Mariana MureaBarry I Freedman

❮ Previous
Next ❯

Datasets Mentioned

BETA
D12485

Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

R
R Foundation for Statistical Computing
R language environment
R Core Team

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.