ENPP1 in the Regulation of Mineralization and Beyond

Trends in Biochemical Sciences
Fiona RobertsV E MacRae

Abstract

ENPP1 is well known for its role in regulating skeletal and soft tissue mineralization. It primarily exerts its function through the generation of pyrophosphate, a key inhibitor of hydroxyapatite formation. Several previous studies have suggested that ENPP1 also contributes to a range of human diseases including diabetes, cancer, cardiovascular disease, and osteoarthritis. In this review, we summarize the pathological roles of ENPP1 in mineralization and these soft tissue disorders. We also discuss the underlying mechanisms through which ENPP1 exerts its pathological effects. A fuller understanding of the pathways through which ENPP1 acts may help to develop novel therapeutic strategies for these commonly diagnosed morbidities.

Citations

Apr 23, 2020·Journal of Cell Science·Karolina LosenkovaGennady G Yegutkin
Nov 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kenneth I OnyedibeHerman O Sintim
Aug 15, 2020·Frontiers in Cell and Developmental Biology·Stephen J BushDavid A Hume
Dec 2, 2020·International Journal of Molecular Sciences·Akiko SuzukiJunichi Iwata
Dec 20, 2020·Biochemical Pharmacology·Gennady G Yegutkin
Mar 14, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Maxwell T Stevens, Bernadette M Saunders
Mar 24, 2021·Cellular and Molecular Life Sciences : CMLS·Massimiliano GasparriniNadia Raffaelli
May 1, 2021·International Journal of Molecular Sciences·Briana K ShimadaOlivier Le Saux
May 1, 2021·International Journal of Molecular Sciences·Holly J WoodwardVictoria E MacRae
Jul 24, 2021·Experimental Dermatology·Zhongtao LiSheng Wang
Jan 16, 2022·Journal of Materials Science. Materials in Medicine·Sara SvenssonPeter Thomsen

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