Enriched environment elevates expression of growth associated protein-43 in the substantia nigra of SAMP8 mice

Neural Regeneration Research
Zhen-Yun YuanMingwei Wang

Abstract

An enriched environment protects dopaminergic neurons from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neuronal injury, but the underlying mechanism for this is not clear. Growth associated protein-43 (GAP-43) is closely associated with neurite outgrowth and axon regeneration during neural development. We speculate that an enriched environment can reduce damage to dopaminergic neurons by affecting the expression of GAP-43. This study is designed to test this hypothesis. Three-month-old female senescence-accelerated mouse prone 8 (SAMP8) mice were housed for 3 months in an enriched environment or a standard environment. These mice were then subcutaneously injected in the abdomen with 14 mg/kg MPTP four times at 2-hour intervals. Morris water maze testing demonstrated that learning and memory abilities were better in the enriched environment group than in the standard environment group. Reverse-transcription polymerase chain reaction, immunohistochemistry and western blot assays showed that mRNA and protein levels of GAP-43 in the substantia nigra were higher after MPTP application in the enriched environment group compared with the standard environment group. These findings indicate that an enriched environment c...Continue Reading

References

Jan 1, 1997·Experimental Gerontology·T TakedaK Higuchi
Mar 10, 1998·Neuroscience and Biobehavioral Reviews·J F Flood, J E Morley
Mar 22, 2001·Nature Reviews. Neuroscience·H van PraagF H Gage
Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Hagai Bergman, Günther Deuschl
May 10, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Adriana Galvan, Thomas Wichmann
Nov 4, 2008·Neuroscience Letters·Jing LiuMing-Wei Wang
May 12, 2009·Neuroscience Letters·Zhen-Yun YuanMing-Wei Wang
Sep 28, 2010·The American Journal of Geriatric Pharmacotherapy·Lindy D WoodErin K Dobbins
Jan 18, 2011·Physiology & Behavior·Vanessa KazlauckasDiogo R Lara
Mar 29, 2011·Neurobiology of Learning and Memory·Pauline ObiangVéronique Agin
Jun 3, 2011·European Journal of Epidemiology·Karin WirdefeldtJack Mandel
Jan 4, 2012·Journal of Ethnopharmacology·Ju-Xian SongYan-Bo Zhang
Jun 27, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Sen-Wei TsaiChuan-Mu Chen
Aug 21, 2012·Learning & Memory·Karsten Baumgärtel, Isabelle M Mansuy
Mar 22, 2014·PloS One·Nicole Rosskothen-Kuhl, Robert-Benjamin Illing
Jun 7, 2014·Behavioural Brain Research·S SchreiberC G Pick
Jul 1, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Tamara PringsheimThomas D L Steeves
Jul 12, 2014·Behavioural Brain Research·Kazuhiro TakumaToshio Matsuda
Dec 9, 2014·Experimental Neurology·Robert J Kotloski, Thomas P Sutula
Jan 16, 2015·Journal of Visualized Experiments : JoVE·Angela M O'ConnorAtomu Sawatari
Feb 1, 2015·European Journal of Pharmacology·Ashish Kumar Kakkar, Neha Dahiya
Feb 5, 2015·Journal of Visualized Experiments : JoVE·Doris TomasTim D Aumann
Mar 11, 2015·Disability and Rehabilitation·Jennifer H WhiteNeil Spratt
Mar 18, 2015·International Journal of Geriatric Psychiatry·John V HindleLinda Clare
Oct 23, 2015·Neuropeptides·Gilliard LachThereza Christina Monteiro de Lima
Dec 20, 2015·Journal of Parkinson's Disease·Guillaume LamotteDaniel M Corcos
Jan 1, 2016·Revue neurologique·A ElbazF Moisan
Mar 30, 2016·Brain Research Bulletin·Lindsay Joy SpielmanAndis Klegeris
May 15, 2016·Parkinsonism & Related Disorders·I-Fan ShihBeate Ritz
Aug 2, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Sara C LaHueCaroline M Tanner
Aug 16, 2016·Clinics in Perinatology·Matthew A Rainaldi, Jeffrey M Perlman
Aug 25, 2016·Neurobiology of Learning and Memory·K MahatiB S Shankaranarayana Rao

❮ Previous
Next ❯

Software Mentioned

Quantity One -
Motic Med
SPSS

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.