Enriched environment influences adrenocortical response to immune challenge and glutamate receptor gene expression in rat hippocampus

Annals of the New York Academy of Sciences
Martin MlynarikD Jezova

Abstract

Housing of animals in an enriched environment (EE) has many positive effects on brain structure and function and can facilitate recovery from various brain injuries. The purpose of this study was to evaluate whether enriched rearing could alter the stress response induced by repeated immune challenge and to investigate the influence of EE and immune challenge on glutamate receptor gene expression in the hippocampus. Male 2-mo-old Wistar rats were kept under standard conditions (SC) or in an EE for 5 weeks. Immune challenge was performed by Escherichia coli lipopolysaccharide (LPS) injected repeatedly (ip) in increasing doses (10, 20, and 40 microg/kg/mL) once daily for five consecutive days. The animals were decapitated 2 h after the last injection. Blood samples, adrenals, and hippocampi were collected. LPS induced an increase in plasma and adrenal levels of corticosterone and a transient decrease in body weight of animals kept under SC, but not in an EE. Enriched housing resulted in an increase in adrenal weights and enhanced gene expression of hippocampal AMPA GluR1 receptor subunit. Concerning the LPS treatment, no effects on adrenal and thymus weights and glutamate receptor mRNA levels in the hippocampus were noticed. Thus...Continue Reading

References

Jan 1, 1992·Advances in Experimental Medicine and Biology·B Will, C Kelche
Aug 29, 1991·The New England Journal of Medicine·S CohenA P Smith
Feb 1, 1973·Journal of Comparative and Physiological Psychology·A GlobusM C Diamond
Apr 1, 1995·Stroke; a Journal of Cerebral Circulation·A L Ohlsson, B B Johansson
Jun 1, 1997·Brain Research. Brain Research Reviews·S J Lupien, B S McEwen
Apr 15, 1999·Annual Review of Neuroscience·B S McEwen
Sep 18, 1999·Science·R C Malenka, R A Nicoll
Dec 29, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R Bernabeu, F R Sharp
Dec 6, 2001·Nature Reviews. Neuroscience·M D Döbrössy, S B Dunnett
Jan 25, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Barbro B Johansson, Pavel V Belichenko
Jan 31, 2002·Psychoneuroendocrinology·John D JohnsonSteven F Maier
Jun 22, 2002·Pharmacology, Biochemistry, and Behavior·Fredrik LarssonAbdul H Mohammed
Oct 31, 2002·Science's STKE : Signal Transduction Knowledge Environment·Anis Contractor, Stephen F Heinemann
Nov 16, 2002·Progress in Brain Research·A H MohammedN Bogdanovic
Mar 20, 2003·Behavioural Brain Research·Gernot RiedelJacques Micheau
Jun 24, 2003·Journal of Rehabilitation Medicine·Barbro B Johansson
Oct 30, 1964·Science·E L BENNETTM R ROSENZWEIG

❮ Previous
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Citations

Apr 4, 2009·Journal of Neural Transmission·Gregorio SegoviaFrancisco Mora
Oct 31, 2006·Chemical Senses·Cynthia C WooMichael Leon
Aug 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Leonardo RestivoMartine Ammassari-Teule
Jan 31, 2012·Brain Research·Francisco MoraPedro Garrido
Jan 8, 2008·Neuroscience and Biobehavioral Reviews·Anandh Dhanushkodi, Ashok K Shetty
Nov 27, 2007·Brain Research Reviews·Francisco MoraAlberto Del Arco
Feb 15, 2007·The European Journal of Neuroscience·Karine MagalonPascale Durbec
Jul 30, 2015·Physiology & Behavior·Damien HuzardMichael A van der Kooij
Jul 21, 2012·Human Brain Mapping·Xianfeng YangAnqi Qiu
Dec 3, 2014·Neuroscience and Biobehavioral Reviews·Elizabeth J CroftonThomas A Green
Mar 14, 2009·Hormones and Behavior·Rebecca M Calisi, George E Bentley
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Myung-Sun KimSung-Rae Cho
Aug 6, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M NickersonM Fleshner
Jan 3, 2014·Physiological Reviews·Alessandro SaleLamberto Maffei
Apr 18, 2017·Stress : the International Journal on the Biology of Stress·Agnesa CsanovaDaniela Jezova
Nov 30, 2019·Pharmacology, Biochemistry, and Behavior·Ewa GalajRobert Ranaldi

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