PMID: 9184641Jun 1, 1997Paper

Enriched immune-environment of blood-brain barrier deficient areas of normal adult rats

Journal of Neuroimmunology
E B PedersenB Finsen

Abstract

The circumventricular organs (CVOs) in the brain are without a blood-brain barrier (BBB) and as such directly exposed to blood plasma constituents and blood-borne pathogens. In light of previous studies showing discrepancies regarding the immunocompetence of these organs, we initiated the present study to provide a comprehensive immunohistochemical analysis of the cellular expression of immune-associated antigens within the pineal gland, area postrema and the subfornical organ. In all CVOs, subpopulations of cells morphologically similar to complement receptor type 3 immunoreactive microglial/macrophage cells expressed major histocompatibility complex (MHC) class II antigen, leucocyte common antigen (LCA/CD45), as well as CD4 and ED1 antigen. Based on morphological criteria the MHC class II antigen expressing cells could be grouped into a major population of classical parenchymal and perivascular ramified microglial cells and a minor population presenting itself as scattered or small groups of rounded macrophage-like cells. CD4 and ED1 antigen were expressed by both cell types. CD45 was preferentially expressed by macrophage-like cells. MHC class I antigen was expressed by the vascular endothelium in both BBB-protected and BBB-...Continue Reading

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Citations

Nov 24, 1999·Brain Research. Developmental Brain Research·F AlliotB Pessac
Dec 11, 2002·Journal of Neurochemistry·Christoph D SchmidMonica J Carson
Oct 4, 2005·Cerebrospinal Fluid Research·Martina Schulz, Britta Engelhardt
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