Enrichment-free analysis of anionic micropollutants in the sub-ppb range in drinking water by capillary electrophoresis-high resolution mass spectrometry.

Analytical and Bioanalytical Chemistry
Oliver HöckerChristian Neusüß

Abstract

Reversed-phase liquid chromatography (RPLC) used for water analysis is not ideal for the analysis of highly polar and ionic contaminants because of low retention. Capillary electrophoresis (CE), on the other hand, is perfectly suited for the separation of ionic compounds but rarely applied in environmental analysis due to the weak concentration sensitivity when coupled to mass spectrometry (MS). However, novel interface designs and MS technology strongly improve the sensitivity. Here, a method is presented enabling the screening of anionic micropollutants in drinking water without sample pretreatment by coupling of CE to an Orbitrap mass spectrometer by a nanoflow sheath liquid interface. Targeted analysis of halogenated acetic acids, trifluoromethanesulfonic acid, and perfluorooctanoic and perfluorooctanesulfonic acid was conducted in drinking water samples which were chlorinated for disinfection. A bare fused silica capillary with an optimized background electrolyte (BGE) for separation consisting of 10% acetic acid with 10% isopropanol with large volume sample injection and optimized interface parameters offer limits of quantification in the range of < 0.1 to 0.5 μg/L with good linearity (R2 > 0.993) and repeatability (14% s...Continue Reading

References

Nov 14, 2007·Journal of Water and Health·Walt Bayless, Robert C Andrews
Mar 17, 2010·Analytical and Bioanalytical Chemistry·Martin KraussJuliane Hollender
Aug 30, 2016·Environmental Science & Technology·Thorsten ReemtsmaPim de Voogt
Nov 8, 2017·Analytical Chemistry·Susan D Richardson, Thomas A Ternes
Mar 23, 2018·Analytical and Bioanalytical Chemistry·Torsten C Schmidt
Sep 21, 2018·Electrophoresis·Rawi RamautarGerhardus J de Jong
Jan 10, 2019·Journal of Exposure Science & Environmental Epidemiology·Alissa CordnerPhil Brown
May 30, 2019·Electrophoresis·Attila GasparAdam Kecskemeti

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Citations

Apr 30, 2021·Analytical Methods : Advancing Methods and Applications·B González-GayaO Zuloaga

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Methods Mentioned

BETA
electrophoresis
metabolomics profiling

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