PMID: 9425103Feb 28, 1998Paper

Enrichment of carnitine palmitoyltransferases I and II in the contact sites of rat liver mitochondria

The Biochemical Journal
F Fraser, V A Zammit

Abstract

The submitochondrial distribution of the overt and latent carnitine palmitoyltransferases (CPT I and II respectively) of rat liver mitochondria were studied. Separation of outer and inner membranes, as well as of a fraction of intermediate density consisting of contact sites between the two membranes, was achieved, as judged by the distribution of marker enzymes. Both CPT I and CPT II were found to be enriched within the contact- site fraction of mitochondria. These data show that the two carnitine acyltransferases are distributed non-uniformly within their respective membranes, and that subpopulations of the two enzymes occur in close proximity within the mitochondrial membrane structure, while retaining their different accessibilities to cytosolic and matrix pools of metabolites. As the number of contact sites is known to vary with changes in the energy status of mitochondria, the possibility that such changes may acutely affect the proportion of CPT I within the distinctive lipid environment of the contact sites, and thus its overall kinetic characteristics, is discussed.

Citations

May 19, 2007·Experimental Cell Research·Yassemi CapetanakiStelios Psarras
Aug 29, 2006·Molecular Genetics and Metabolism·Naomi van VliesFrédéric M Vaz
Dec 24, 2013·International Journal of Alzheimer's Disease·Nathalie ArnalCarlos A Marra
Sep 26, 2000·Molecular Genetics and Metabolism·F R van der LeijB Bartelds
Sep 15, 2004·Molecular Aspects of Medicine·Rona R Ramsay, Victor A Zammit
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Dec 12, 2001·Acta Physiologica Scandinavica·J SlebodaR S Horn
Apr 19, 2008·IUBMB Life·Victor A Zammit
May 12, 2009·Cellular and Molecular Life Sciences : CMLS·Arne C RuferMichael Hennig
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