Enrichment of immunoregulatory proteins in the biomolecular corona of nanoparticles within human respiratory tract lining fluid

Nanomedicine : Nanotechnology, Biology, and Medicine
Abhinav KumarIan S Mudway

Abstract

When inhaled nanoparticles deposit in the lungs, they transit through respiratory tract lining fluid (RTLF) acquiring a biomolecular corona reflecting the interaction of the RTLF with the nanomaterial surface. Label-free snapshot proteomics was used to generate semi-quantitative profiles of corona proteins formed around silica (SiO2) and poly(vinyl) acetate (PVAc) nanoparticles in RTLF, the latter employed as an archetype drug delivery vehicle. The evolved PVAc corona was significantly enriched compared to that observed on SiO2 nanoparticles (698 vs. 429 proteins identified); however both coronas contained a substantial contribution from innate immunity proteins, including surfactant protein A, napsin A and complement (C1q and C3) proteins. Functional protein classification supports the hypothesis that corona formation in RTLF constitutes opsonisation, preparing particles for phagocytosis and clearance from the lungs. These data highlight how an understanding of the evolved corona is necessary for the design of inhaled nanomedicines with acceptable safety and tailored clearance profiles. Inhaled nanoparticles often acquire a layer of protein corona while they go through the respiratory tract. Here, the authors investigated the ...Continue Reading

References

Jan 1, 1994·Micron : the International Research and Review Journal for Microscopy·Y Tahara, Y Fujiyoshi
Oct 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Wendy T WatfordJo Rae Wright
Oct 4, 2005·Molecular & Cellular Proteomics : MCP·Yan HuDavid M Holtzman
Oct 11, 2005·Molecular Immunology·Uday KishoreTrinad Chakraborty
Apr 4, 2006·Current Opinion in Pharmacology·Paul S Kingma, Jeffrey A Whitsett
Apr 8, 2006·Chemistry and Physics of Lipids·Alicia G Serrano, Jesús Pérez-Gil
Apr 21, 2006·International Journal of Pharmaceutics·Xiaomei Mu, Zhensheng Zhong
Oct 20, 2007·Clinical Physiology and Functional Imaging·Dan WaismanYeshayahu Talmon
Nov 1, 2007·Expert Opinion on Drug Delivery·Philippe Ga Rogueda, Daniela Traini
Nov 1, 2007·Expert Opinion on Drug Delivery·Philippe Ga Rogueda, Daniela Traini
May 23, 2009·Inhalation Toxicology·Mine Orlu GulBen Forbes
Jun 16, 2009·Nature Materials·Andre E NelMike Thompson
Jun 30, 2009·Inhalation Toxicology·Carsten Schleh, Jens M Hohlfeld
Jun 18, 2010·ACS Nano·Eudald CasalsVictor Puntes
Nov 5, 2010·The Journal of Biological Chemistry·Christine T N PhamDennis E Hourcade
Nov 9, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Christine SchulzeClaus-Michael Lehr
Nov 9, 2010·Nature Biotechnology·Hak Soo ChoiAkira Tsuda
Dec 4, 2010·Particle and Fibre Toxicology·Dorota NapierskaPeter H Hoet
Dec 9, 2010·Nature Biotechnology·Wolfgang G KreylingCarsten Schleh
Feb 4, 2011·Journal of the American Chemical Society·Marco P MonopoliKenneth A Dawson
Aug 16, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Christian A RugeClaus-Michael Lehr
Nov 18, 2011·Biomaterials·Erwin A Vogler
Apr 21, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Eugene MahonKenneth A Dawson
Jul 19, 2012·ACS Nano·James Chen Yong KahKimberly Hamad-Schifferli
Dec 6, 2012·Nature Nanotechnology·Marco P MonopoliKenneth A Dawson
Mar 28, 2013·Particle and Fibre Toxicology·Carsten SchlehClaus-Michael Lehr
Sep 24, 2013·Nature Nanotechnology·Stefan TenzerRoland H Stauber
Nov 12, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Christine T N PhamDennis E Hourcade
Mar 13, 2014·Proteomics. Clinical Applications·Elizabeth V NguyenDavid R Goodlett
Mar 25, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marie-Christine JonesLea Ann Dailey
Jun 25, 2014·American Journal of Respiratory Cell and Molecular Biology·Julie G LedfordLoretta G Que
Sep 30, 2014·Colloids and Surfaces. B, Biointerfaces·Shahed BehzadiMorteza Mahmoudi
Oct 14, 2014·Cancer Nanotechnology·Emilie Brun, Cécile Sicard-Roselli
Jan 4, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Giulio Caracciolo

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Citations

Mar 20, 2016·The International Journal of Biochemistry & Cell Biology·Sha WanMarco P Monopoli
Sep 20, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Moritz Beck-Broichsitter
Nov 17, 2016·Drug Delivery and Translational Research·Kamal DuaPhilip M Hansbro
Mar 16, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Francesca PederzoliBarbara Ruozi
Jun 26, 2017·Nanomedicine : Nanotechnology, Biology, and Medicine·Abhinav KumarIan Mudway
Oct 13, 2017·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Ali DabbaghNoorsaadah Abdul Rahman
Nov 30, 2018·Expert Opinion on Drug Delivery·Regina Scherließ
Jul 3, 2019·Biosensors·Masauso Moses PhiriBarend Christiaan Vorster
Feb 20, 2020·Expert Opinion on Drug Delivery·Ali KeshavarzFakhrul Ahsan
May 22, 2019·Nanotoxicology·Moritz Beck-Broichsitter, Adam Bohr
Apr 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xinyi Chen, Changyou Gao
Apr 3, 2018·Nanotechnology Reviews·Jonathan Shannahan
Aug 14, 2018·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Daniel NierenbergOrielyz Flores
Dec 20, 2019·ACS Nano·Le-Phuong-Anh ThaiJean-François Berret
Jun 16, 2018·ACS Applied Materials & Interfaces·Giulio CaraccioloAldo Laganà
Dec 9, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Moritz Beck-Broichsitter
Aug 17, 2017·Molecular Pharmaceutics·Moritz Beck-BroichsitterChristian A Ruge
May 15, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Nagarjun V KonduruRamon M Molina

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