Enrichment of magnetic particles using temperature and magnetic field gradients induced by benchtop fabricated micro-electromagnets

Lab on a Chip
A HosseiniL Soleymani

Abstract

The active transport of analytes inside biosensing systems is important for reducing the response time and enhancing the limit-of-detection of these systems. Due to the ease of functionalization with bio-recognition agents and manipulation with magnetic fields, magnetic particles are widely used for active and directed transport of biological analytes. On-chip active electromagnets are ideally suited for manipulating magnetic particles in an automated and miniaturized fashion inside biosensing systems. Unfortunately, the magnetic force exerted by these devices decays rapidly as we move away from the device edges, and increasing the generated force to the levels necessary for particle manipulation requires a parallel increase in the applied current and the resultant Joule heating. In this paper, we designed a study to understand the combined role of thermal and magnetic forces on the movement of magnetic particles in order to extend the interaction distance of on-chip magnetic devices beyond the device edges. For this purpose, we used a rapid prototyping method to create an active/passive on-chip electromagnet with a micro/nano-structured active layer and a patterned ferromagnetic passive layer. We demonstrated that the measured...Continue Reading

References

Jun 19, 2002·Analytical Chemistry·David Ross, Laurie E Locascio
Aug 21, 2003·Journal of the American Chemical Society·J Manuel PerezRalph Weissleder
Oct 3, 2003·Biomagnetic Research and Technology·ZM SaiyedCN Ramchand
Apr 22, 2004·Lab on a Chip·David EricksonDongqing Li
May 13, 2004·Journal of the American Chemical Society·Jwa-Min NamChad A Mirkin
Nov 13, 2004·Angewandte Chemie·Eugenii Katz, Itamar Willner
Apr 14, 2005·Nano Letters·Paul E Sheehan, Lloyd J Whitman
Oct 6, 2005·Biosensors & Bioelectronics·Qasem RamadanChen Yu
Dec 24, 2005·Lab on a Chip·Nicole Pamme
Dec 1, 2006·Analytical Chemistry·Sun Min KimErnest F Hasselbrink
Feb 6, 2007·Angewandte Chemie·An-Hui LuFerdi Schüth
Oct 26, 2007·Lab on a Chip·Hope C FeldmanCarl D Meinhart
Mar 12, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Shuangyan XuStephen H Garofalini
Jul 7, 2009·Analytical and Bioanalytical Chemistry·C ZhangK Kalantar-Zadeh
Jul 17, 2009·Lab on a Chip·Di WeiTapani Ryhänen
Dec 8, 2009·Chemical Reviews·Martin A M GijsUlrike Lehmann
Oct 12, 2010·Biosensors & Bioelectronics·Khashayar KhoshmaneshKourosh Kalantar-zadeh
Nov 23, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Joseph R BasoreLane A Baker
May 19, 2012·Journal of the American Chemical Society·Kuo-Tang Liao, Chia-Fu Chou
Mar 13, 2013·Applied Physics Letters·Dharmakeerthi NawarathnaMichelle Khine
Dec 30, 2014·Lab on a Chip·Majid HejazianNam-Trung Nguyen
Dec 9, 2015·Angewandte Chemie·Brenda J GreenShana O Kelley

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Methods Mentioned

BETA
biosensor
biosensors
biosensing
chip
chips
X-ray

Software Mentioned

COMSOL Multiphyiscs
Adobe Illustrator
COMSOL Multiphysics

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