Enrofloxacin and macrolides alone or in combination with rifampicin as antimicrobial treatment in a bovine model of acute Chlamydia psittaci infection

PloS One
Annette ProhlPetra Reinhold

Abstract

Chlamydia psittaci is a zoonotic bacterium with a wide host range that can cause respiratory disease in humans and cattle. In the present study, effects of treatment with macrolides and quinolones applied alone or in combination with rifampicin were tested in a previously established bovine model of respiratory C. psittaci infection. Fifty animals were inoculated intrabronchially at the age of 6-8 weeks. Seven served as untreated controls, the others were assigned to seven treatment groups: (i) rifampicin, (ii) enrofloxacin, (iii) enrofloxacin + rifampicin, (iv) azithromycin, (v) azithromycin + rifampicin, (vi) erythromycin, and (vii) erythromycin + rifampicin. Treatment started 30 hours after inoculation and continued until 14 days after inoculation (dpi), when all animals were necropsied. The infection was successful in all animals and sufficient antibiotic levels were detected in blood plasma and tissue of the treated animals. Reisolation of the pathogen was achieved more often from untreated animals than from other groups. Nevertheless, pathogen detection by PCR was possible to the same extent in all animals and there were no significant differences between treated and untreated animals in terms of local (i.e., cell count a...Continue Reading

References

Mar 1, 1978·Clinical Pharmacokinetics·G Acocella
Jul 1, 1991·International Journal of STD & AIDS·J D WhatleyG L Ridgway
Oct 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H Lode
Nov 1, 1991·The Veterinary Clinics of North America. Food Animal Practice·G St-Jean, A D Jernigan
Jul 1, 1983·Reviews of Infectious Diseases·W Wehrli
Jul 1, 1983·Reviews of Infectious Diseases·G Acocella
Jul 1, 1983·Reviews of Infectious Diseases·C ThornsberryL K McDougal
Jun 1, 1993·The Journal of Antimicrobial Chemotherapy·P J ListerA J Robinson
Oct 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·L KaartinenS Pyörälä
Jan 7, 1998·Antimicrobial Agents and Chemotherapy·P ButayeF Haesebrouck
Nov 5, 1998·The Pediatric Infectious Disease Journal·J A HarrisM R Hammerschlag
Jun 16, 2000·International Journal of Antimicrobial Agents·M R Hammerschlag, P M Roblin
Jul 14, 2001·Antimicrobial Agents and Chemotherapy·J LenartD D Rockey
May 11, 2002·The Journal of Antimicrobial Chemotherapy·I MorrisseyG Ridgway
Sep 10, 2002·Sexually Transmitted Diseases·Chuen-Yen Lau, Azhar K Qureshi
Oct 1, 1952·Proceedings of the Society for Experimental Biology and Medicine·T H HAIGHT, M FINLAND
Mar 18, 2004·The British Journal of Ophthalmology·I R Schwab, J Marshall
Feb 18, 2005·The Journal of Infectious Diseases·Monica MolanoAdriaan J C van den Brule
Jun 28, 2005·Antimicrobial Agents and Chemotherapy·Rachel Binet, Anthony T Maurelli
Oct 13, 2005·Expert Opinion on Pharmacotherapy·Laurence SennGilbert Greub
Oct 28, 2005·Antimicrobial Agents and Chemotherapy·Rachel Binet, Anthony T Maurelli
Dec 7, 2005·Molecular and Cellular Probes·Ralf EhrichtKonrad Sachse
Jul 14, 2006·Theriogenology·Johannes KauffoldKonrad Sachse
Oct 13, 2006·Journal of Medical Microbiology·Edou R HeddemaChristina M J E Vandenbroucke-Grauls
Nov 8, 2006·Animal Reproduction Science·Johannes KauffoldFalk Melzer
Jan 11, 2007·Journal of Vision·Jan W BrascampAlbert V van den Berg
Feb 24, 2007·The Veterinary Journal·Petra ReinholdKonrad Sachse

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Citations

Jul 26, 2015·BMC Veterinary Research·Annette ProhlPetra Reinhold
Feb 20, 2019·Frontiers in Microbiology·Sankhya Bommana, Adam Polkinghorne
Apr 23, 2020·International Journal of Molecular Sciences·Elisabeth M Liebler-TenorioPetra Reinhold
Jul 28, 2021·Tropical Animal Health and Production·Karthikeyan RavichandranBalusamy Dhayananth

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Methods Mentioned

BETA
PCR
enzyme-linked immunosorbent assay
bronchoalveolar
lavage
biopsies
ELISA

Software Mentioned

nparcomp
Plotrix
coin

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