PMID: 8587153Oct 1, 1995Paper

Enrofloxacin-theophylline interaction: influence of enrofloxacin on theophylline steady-state pharmacokinetics in the beagle dog

Journal of Veterinary Pharmacology and Therapeutics
L IntorreG Soldani

Abstract

Enrofloxacin, a quinolone antibiotic developed exclusively for use in animals, was investigated for its effects on the steady-state pharmacokinetics of theophylline in six healthy Beagle dogs. A sustained-release theophylline formulation was given alone (20 mg/kg per os twice daily at 12 h intervals) for 9 days and then co-administered with enrofloxacin (5 mg/kg i.v. once a day) for 5 days. Mean trough theophylline concentrations progressively and significantly increased during the five days of enrofloxacin co-administration. Theophylline clearance and concentration-time profile were significantly changed by enrofloxacin co-administration. No significant change was observed in enrofloxacin pharmacokinetics. The kinetic interaction between theophylline and enrofloxacin could be of clinical significance and may require plasma drug concentration monitoring and adjustment of theophylline dosage.

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Citations

Feb 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·S A Brown
Feb 23, 2007·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·A Rae GandolfMark W Atkinson
Dec 30, 2008·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Robert P Hunter, Ramiro Isaza
Feb 26, 2013·Drug Metabolism Reviews·Marilyn N MartinezLauren Trepanier
Jun 29, 2010·Research in Veterinary Science·Ling-Ling ZhangShan-Xiang Jiang
Aug 1, 2015·Journal of Veterinary Pharmacology and Therapeutics·C W LocusonJ S Daniels
Sep 21, 2006·The Veterinary Clinics of North America. Small Animal Practice·Lauren A Trepanier
Feb 22, 2005·Journal of Veterinary Pharmacology and Therapeutics·P K SidhuP Lees
Dec 14, 2005·Journal of Veterinary Pharmacology and Therapeutics·N L RegmiM Shimoda
Jan 16, 2007·Journal of Veterinary Pharmacology and Therapeutics·N L RegmiM Shimoda
Sep 9, 2006·Journal of Veterinary Pharmacology and Therapeutics·N L RegmiM Shimoda
Jun 23, 2011·Journal of Veterinary Pharmacology and Therapeutics·B KuKanich, J L Nauss
Jan 12, 2012·Journal of Veterinary Pharmacology and Therapeutics·S CoxT Doherty
Jul 6, 2011·Journal of Veterinary Pharmacology and Therapeutics·X HuJ-F Zhou
Aug 11, 2015·Journal of Advanced Research·Kazuaki Sasaki, Minoru Shimoda
May 19, 2019·Journal of Veterinary Pharmacology and Therapeutics·Prabhakaran VinothiniPadmanabhan Sriram
Apr 16, 2014·Journal of Veterinary Pharmacology and Therapeutics·M SlanaM Sollner-Dolenc
Dec 17, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Beth Miskimins MillsCharles W Locuson
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Sep 19, 2019·Journal of Veterinary Pharmacology and Therapeutics·Carrie L CavettJennifer M Reinhart
May 1, 2021·Veterinary Sciences·Tussapon BoonyarattanasoonthornAnusak Kijtawornrat
Oct 31, 1997·Journal of Pharmaceutical Sciences·C C Cester, P L Toutain

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