Ensemble codes involving hippocampal neurons are at risk during delayed performance tests

Proceedings of the National Academy of Sciences of the United States of America
R E Hampson, S A Deadwyler

Abstract

Multielectrode recording techniques were used to record ensemble activity from 10 to 16 simultaneously active CA1 and CA3 neurons in the rat hippocampus during performance of a spatial delayed-nonmatch-to-sample task. Extracted sources of variance were used to assess the nature of two different types of errors that accounted for 30% of total trials. The two types of errors included ensemble "miscodes" of sample phase information and errors associated with delay-dependent corruption or disappearance of sample information at the time of the nonmatch response. Statistical assessment of trial sequences and associated "strength" of hippocampal ensemble codes revealed that miscoded error trials always followed delay-dependent error trials in which encoding was "weak," indicating that the two types of errors were "linked." It was determined that the occurrence of weakly encoded, delay-dependent error trials initiated an ensemble encoding "strategy" that increased the chances of being correct on the next trial and avoided the occurrence of further delay-dependent errors. Unexpectedly, the strategy involved "strongly" encoding response position information from the prior (delay-dependent) error trial and carrying it forward to the sampl...Continue Reading

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Citations

Aug 26, 1999·Life Sciences·R E Hampson, S A Deadwyler
Jul 31, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James David JentschAntonieta Lavin
Sep 28, 1998·The European Journal of Neuroscience·C J PlonerC Pierrot-Deseilligny
Jun 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Pamela J Kennedy, Matthew L Shapiro
Oct 28, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jonathan K KleenPierre-Pascal Lenck-Santini
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·P S Goldman-Rakic
May 29, 2008·Journal of Computational Neuroscience·Dong SongTheodore W Berger
Jan 9, 2013·Behavioural Brain Research·R Jonathan RobitsekHoward Eichenbaum
May 12, 2004·Neuron·Sam A Deadwyler, Robert E Hampson
Jun 12, 2013·Journal of Physiology, Paris·Yoshio SakuraiSusumu Takahashi
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Mar 17, 2004·Journal of Neuroscience Methods·Guglielmo Foffani, Karen Anne Moxon
Sep 18, 2016·Journal of Molecular Neuroscience : MN·A ShepherdE L Burrows
Apr 7, 2005·Behavioral and Cognitive Neuroscience Reviews·John K Robinson
Nov 6, 2007·Hippocampus·Eric A Zilli, Michael E Hasselmo
Jan 1, 1997·Annual Review of Neuroscience·S A Deadwyler, R E Hampson

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