Ensuring comparability of benzene exposure estimates across three nested case-control studies in the petroleum industry in support of a pooled epidemiological analysis

Chemico-biological Interactions
D C GlassL Rushton

Abstract

Three case-control studies each nested within a cohort of petroleum workers assessed exposure to benzene in relation to risk of haematopoietic cancers. These studies have each been updated and the cases will be pooled to derive a more powerful study. The benzene exposure of new leukemia cases and controls was estimated in accordance with each respective study's original methods. An essential component of the process of pooling the data was comparison and rationalisation of the exposure estimates to ensure accuracy and consistency of approach. This paper describes this process and presents comparative estimates before and after appropriate revision took place. The original petroleum industry studies, in Canada, the UK and Australia, were conducted at different points in time by different study teams, but the industry used similar technology in similar eras in each of these countries. A job history for each subject giving job title, dates of starting and leaving the job and location of work, was assembled. For each job or task, the average benzene exposure (Base Estimate (BE) in ppm) was derived from measurements collected at applicable worksites. Estimates of exposure intensity (workplace exposure estimates (WE)) were then calcu...Continue Reading

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Citations

Nov 1, 2012·Journal of the National Cancer Institute·A Robert SchnatterLesley Rushton
Jan 15, 2015·International Journal of Environmental Research and Public Health·Benjamin EdokpoloDes Connell
Oct 31, 2015·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Pamela R D Williams, Ashutosh Mani
Jul 15, 2015·International Journal of Epidemiology·Deborah C GlassMalcolm R Sim
Jun 27, 2017·Journal of Occupational and Environmental Hygiene·D C GlassL Rushton
Apr 20, 2018·Journal of Occupational and Environmental Hygiene·Michael FriesAndrew Maier
Mar 30, 2019·Risk Analysis : an Official Publication of the Society for Risk Analysis·Harvey CheckowayKenneth A Mundt
Aug 24, 2011·Toxicology Mechanisms and Methods·David W PyattColleen A Cushing
May 8, 2018·Occupational and Environmental Medicine·Michelle C Turner, Ingrid Sivesind Mehlum

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