ent-Kaurane Diterpenoids with Neuroprotective Properties from Corn Silk ( Zea mays)

Journal of Natural Products
Xiao-Li QiShao-Jiang Song

Abstract

Thirteen new ent-kaurane diterpenoids, stigmaydenes A-M (1-13), together with two known compounds (14, 15), were isolated from the crude extract of corn silk ( Zea mays). The structures of the compounds were confirmed by comprehensive spectroscopic analyses. The absolute configuration of compound 1 was defined by single-crystal X-ray diffraction. The absolute configurations of the compounds were also confirmed by comparison of experimental and calculated specific rotations. The compounds were evaluated for their neuroprotective effects against H2O2-induced SH-SY5Y cell injury, and compound 8 was active at 100 μM, as determined by flow cytometry (annexin V-FITC/PI staining) and Hoechst 33258 staining. The results suggested that compound 8 could protect neuronal cells from H2O2-induced injury by inhibiting apoptosis in SH-SY5Y cells.

References

Oct 26, 2002·Journal of Natural Products·Yu-Liang YangYang-Chang Wu
Mar 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Eric A SchmelzPeter E Teal
Jan 24, 2014·The Plant Journal : for Cell and Molecular Biology·Eric A SchmelzReuben J Peters
Oct 17, 2015·Phytochemistry·Hongjie MaoQiang Wang
Feb 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Sibongile MafuReuben J Peters
Dec 15, 2016·Journal of the American Chemical Society·Jeffrey D RudolfBen Shen

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Citations

Sep 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tommaso StefaniMaría Del Rayo Camacho-Corona
Nov 12, 2019·Natural Product Research·Wei-Yu ZhouShao-Jiang Song
Mar 28, 2019·Journal of Natural Products·Wen-Yu ZhaoShao-Jiang Song

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis