PMID: 11927043Apr 3, 2002Paper

Entamoeba histolytica: Clinical Update and Vaccine Prospects

Current Infectious Disease Reports
William A Petri

Abstract

Amebiasis is extraordinarily common in children of the developing world. This realization has come from application of diagnostic techniques that distinguish the nonpathogenic parasite Entamoeba dispar from Entamoeba histolytica. E. histolytica infection is found in children with dysentery, diarrhea, and in many cases in children with no gastrointestinal symptoms. Genetically distinct strains of E. histolytica exist but evidence is too preliminary to judge if some strains are more virulent than others. A provocative study from Tanzania has shown that pregnant women with HIV infection who are coinfected with E. histolytica are at greater risk of delivering a low birth weight infant. Perhaps the most exciting new data is the identification of acquired immunity to recurrent E. histolytica infection. Acquired immunity is linked to a mucosal immune response against a major virulence factor of the parasite, a Gal/GalNAc lectin responsible for adherence and killing of the host. Prospects for a vaccine are thus brightening at the same time that the true burden of disease is comprehended.

References

Dec 19, 2000·Infection and Immunity·L H Kasper, D Buzoni-Gatel
Jan 9, 2001·Clinical Microbiology Reviews·P Upcroft, J A Upcroft
Mar 7, 2001·Journal of Clinical Microbiology·M Zaki, C G Clark
Mar 16, 2001·The Journal of Eukaryotic Microbiology·D Eichinger
May 17, 2001·Antimicrobial Agents and Chemotherapy·J A Upcroft, P Upcroft
Jun 22, 2001·Journal of Clinical Gastroenterology·C J LiuD S Chen
Jul 27, 2001·The Journal of Infectious Diseases·S L Stanley
Jul 31, 2001·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M SchunkH D Nothdurft
Aug 17, 2001·Internal Medicine·K Amano, T Takeuchi
Oct 6, 2001·Gastroenterology Clinics of North America·D E Katz, D N Taylor
Nov 6, 2001·The American Journal of Tropical Medicine and Hygiene·L L BragaB J Mann
Nov 28, 2001·The American Journal of Clinical Nutrition·M L DreyfussW W Fawzi

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Citations

Apr 14, 2005·International Journal for Parasitology·E A Worthey, P J Myler
May 26, 2010·BMC Genomics·Derek M HuntleyJohn P Ackers
Jan 10, 2014·North American Journal of Medical Sciences·Amal NaousMariam Rajab
Jan 5, 2013·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Moustafa Abdelaal HegaziBasem Salama El-Deek
Dec 21, 2006·Molecular and Biochemical Parasitology·Abdirashid M Shire, John P Ackers

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