Entangled radicals may explain lithium effects on hyperactivity.

Scientific Reports
Hadi Zadeh-Haghighi, Christoph Simon

Abstract

It is known that bipolar disorder and its lithium treatment involve the modulation of oxidative stress. Moreover, it has been observed that lithium's effects are isotope-dependent. Based on these findings, here we propose that lithium exerts its effects by influencing the recombination dynamics of a naturally occurring radical pair involving oxygen. We develop a simple model inspired by the radical-pair mechanism in cryptochrome in the context of avian magnetoreception and xenon-induced anesthesia. Our model reproduces the observed isotopic dependence in the lithium treatment of hyperactivity in rats. It predicts a magnetic-field dependence of the effectiveness of lithium, which provides one potential experimental test of our hypothesis. Our findings show that Nature might harness quantum entanglement for the brain's cognitive processes.

References

Jan 1, 1989·Chemico-biological Interactions·J R Kanofsky
Nov 1, 1986·Biological Psychiatry·J A SechzerP E Stokes
Mar 1, 1996·Schizophrenia Research·S P Mahadik, S Mukherjee
Feb 2, 2000·Biophysical Journal·T RitzK Schulten
Feb 13, 2001·Biochemical and Biophysical Research Communications·W J Ryves, A J Harwood
Aug 22, 2001·Psychological Medicine·S L McColl, J A Veitch
Apr 1, 2003·Annals of Neurology·Peter Jenner
May 6, 2003·Nature Structural Biology·Baldissera GiovaniKlaus Brettel
Feb 3, 2004·The American Journal of Psychiatry·Anabel Martínez-AránManel Salamero
Jul 13, 2006·Expert Review of Neurotherapeutics·Dietmar WinklerSiegfried Kasper
Jul 25, 2006·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Venkataramanujan SrinivasanDaniel P Cardinali
Jan 22, 2008·The International Journal of Neuropsychopharmacology·Felicity NgAshley I Bush
Jun 10, 2008·Journal of Affective Disorders·Ana C AndreazzaLakshmi N Yatham
Sep 20, 2008·Nature Reviews. Genetics·Joseph S TakahashiErin L McDearmon
Jun 17, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Mehmet YumruOzcan Erel
Jul 30, 2009·Environmental Health : a Global Access Science Source·Shia T KentNalini Sathiakumar
Feb 13, 2010·Annual Review of Physiology·David K WelshSteve A Kay
Mar 3, 2010·PloS One·Catharina LavebrattMartin Schalling
May 11, 2010·Issues in Mental Health Nursing·Sue PenckoferCarol Estwing Ferrans
Sep 14, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Hayley B ClayChristine Konradi
Sep 15, 2010·Journal of Psychopharmacology·Teresa M OslandVidar M Steen
Apr 16, 2011·Trends in Pharmacological Sciences·Mehdi Ghasemi, Ahmad Reza Dehpour
Jun 17, 2011·Nature·Philip Ball
Aug 4, 2011·Neuropsychobiology·Gerald PailSiegfried Kasper
Mar 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kiminori MaedaP J Hore
Apr 17, 2012·Drugs & Aging·Orestes V ForlenzaWagner F Gattaz
Jul 24, 2012·Trends in Biochemical Sciences·Pimchai ChaiyenAndrea Mattevi
Oct 2, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seung-Yup LeeChi-Un Pae
May 15, 2013·Lancet·John R Geddes, David J Miklowitz
Sep 28, 2013·Physics of Life Reviews·Stuart Hameroff, Roger Penrose
Dec 18, 2013·Journal of Psychiatric Research·Rafael T de SousaRodrigo Machado-Vieira
Mar 29, 2014·Current Neuropharmacology·Samina Salim
Apr 15, 2014·Journal of Photochemistry and Photobiology. B, Biology·Michal Cifra, Pavel Pospíšil
May 6, 2014·Psychiatry Research·Nicole C BrownL Trevor Young

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