Entecavir treatment of chronic hepatitis D

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Gökhan KabaçamCihan Yurdaydìn

Abstract

Hepatitis D virus (HDV) requires hepatitis B surface antigen (HBsAg) to propagate infection and cause disease. Entecavir is a nucleoside analog with potent antiviral efficacy, and in the woodchuck animal model it also decreased hepatitis B virus (HBV) cccDNA and woodchuck surface antigen. The aim of this study was to investigate the efficacy of entecavir in chronic hepatitis D (CHD). This single-center study was conducted in patients with compensated liver disease. All patients had to have detectable hepatitis HDV RNA and elevated levels of alanine aminotransferase (ALT). Entecavir was given at a dosage of 1 mg/d for 1 year. The primary end point was achievement of undetectable HDV RNA at the end of treatment. Thirteen consecutive patients were assessed. All patients had detectable HDV RNA, and 8 had detectable HBV DNA at baseline. At the end of treatment, HBV DNA became undetectable in all patients (P = .001). No significant decline in HDV RNA, ALT, or quantitative HBsAg levels was observed. The primary end point of undetectable HDV RNA at the end of treatment was achieved in 3 patients who had significantly lower baseline HDV RNA levels than nonresponders (2.99 log(10) copies/mL ± .70 vs 4.68 ± .97; P = .0185). In all 3 patie...Continue Reading

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Citations

Dec 18, 2012·Current Infectious Disease Reports·Benjamin HeidrichHeiner Wedemeyer
Aug 9, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Wang-Huei ShengShan-Chwen Chang
Sep 11, 2013·Nature Reviews. Gastroenterology & Hepatology·Alessia Ciancio, Mario Rizzetto
Mar 7, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chien-Ching HungSui-Yuan Chang
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