Enteral nutrition provided within 48 hours after admission in severe acute pancreatitis: A systematic review and meta-analysis

Medicine
Jianbo SongLiying Pei

Abstract

Whether to conduct enteral nutrition in patients with severe acute pancreatitis (SAP) during the active phase of intestinal stress or to feed during remission remains controversial. This study was aimed to evaluate the efficacy and safety of enteral nutrition within 48 hours after admission in the patients with SAP or predicted severe acute pancreatitis (pSAP). We searched PubMed, EMBASE, Web of Science, and the Cochrane Library before December 2017. Randomized controlled trials of early enteral nutrition (starting within 48 hours after admission) versus late enteral nutrition or total parental nutrition in severe acute pancreatitis or predicted severe acute pancreatitis were selected. Ten randomized controlled trials containing 1051 patients were included. Comparing early enteral nutrition to late enteral nutrition or total parental nutrition in SAP or pSAP, the pooled risk ratios were 0.53 (95% confidence interval [CI] 0.35-0.81, P = .003) for mortality, 0.58 (95% CI 0.43-0.77, P = .0002) for multiple organ failure (MOF), 0.50 (95% CI 0.33-0.75, P = .0008) for operative intervention, 0.75 (95% CI 0.61-0.93, P = .009) for systemic infection, 0.42 (95% CI 0.26-0.69, P = .0005) for local septic complications, 0.84 (95% CI 0.74-0...Continue Reading

References

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Citations

Sep 20, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Meera Ramanathan, Abdul Aziz Aadam
Mar 19, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Xinrong ChenKa Li
May 21, 2020·World Journal of Clinical Cases·Narisorn Lakananurak, Leah Gramlich
Feb 1, 2019·Current Treatment Options in Gastroenterology·Mahya FaghihVikesh K Singh
Feb 6, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Marianna ArvanitakisStephan C Bischoff
Mar 7, 2021·Journal of Clinical Medicine·Allison L Yang
Mar 22, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Jakob BurcharthIsmail Gögenur
Mar 22, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Hideto YasudaToshihiko Mayumi
May 1, 2021·Nutrients·Beata Jabłońska, Sławomir Mrowiec
Jul 14, 2021·World Journal of Pediatrics : WJP·Hong ZhaoJin-Gan Lou

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