Enteral topiramate in a pediatric patient with refractory status epilepticus: a case report and review of the literature

The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG
Chasity M SheltonStephanie J Phelps

Abstract

We describe the use of topiramate in a healthy 12-year-old (88-kg) male who developed refractory generalized convulsive status epilepticus. Seizures persisted despite aggressive use of benzodiazepines (intravenous lorazepam; oral clorazepate), barbiturates (i.e., phenobarbital, pentobarbital), and hydantoins. The child's seizures were controlled with nasogastrically administered topiramate in doses up to 500 mg twice daily (11.4 mg/kg/day). The patient did not display any clinical or laboratory signs of metabolic acidosis while receiving topiramate. Topiramate should be considered as a treatment option in refractory status epilepticus.

References

Apr 18, 2000·Epilepsia·S J DodgsonB E Maryanoff
Jul 7, 2001·Epilepsia·O A PetroffR H Mattson
Jul 10, 2001·Epilepsia·M TakeokaJ J Riviello
Jan 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M ReuberJ M Bamford
Feb 15, 2002·Archives of Neurology·Stephan A MayerBrian-Fred Fitzsimmons
Jan 29, 2003·Neurology·A R TowneR J DeLorenzo
Mar 1, 2003·Epilepsy & Behavior : E&B·Toufic FakhouryBassel Abou-Khalil
Sep 27, 2003·Epilepsia·Mustafa KahrimanAhmad Beydoun
Dec 31, 2003·Epilepsy & Behavior : E&B·Meriem K Bensalem, Toufic A Fakhoury
Feb 6, 2004·JAMA : the Journal of the American Medical Association·Suzette M LaRoche, Sandra L Helmers
Jul 24, 2004·Anaesthesia·Y Ozer, H Altunkaya
Apr 19, 2005·Journal of Child Neurology·Lubov BlumkinNathan Watemberg
Jul 11, 2006·Epilepsia·M Scott PerryJohn T Sladky
Dec 21, 2007·Epilepsia·Florise A C P Lambrechtsen, Jeffrey R Buchhalter
Apr 9, 2010·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Michael J LynchMatthew D Krasowski
Mar 29, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Başak Nur Akyildiz, Sefer Kumandaş
Jun 30, 2011·Acta Neurologica Scandinavica·V Stojanova, A O Rossetti
Jul 15, 2011·Arquivos de neuro-psiquiatria·José Augusto BragattiMarino Muxfeldt Bianchin

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